Centre National De La Recherche Scientifique

Université De Bourgogne

UniversitÉde Strasbourg

Synthelor Sas

Jerome Bayardon

Sylvain Juge

Emmanuelle Remond

Frederic R Leroux

Hugo Laureano

Jean-Christophe Henry

Francoise Colobert

Marie-Joelle Ondel-Eymin

P-chirogenic organophosphorus compounds of general formula (I), a process for the synthesis of the compounds of formula (I), and intermediate products of general formulae (II), (III) and (IV), as shown below, are involved in the synthesis of compounds (I).  Metal complexes comprising compounds (I) as ligands are also described. The compounds and complexes are useful in asymmetric catalysis by transition metal complexes or organocatalysis, especially for asymmetric hydrogenation or allylation. Compounds of general formula (I) may be useful as agrochemical and therapeutic substances, or as reagents or intermediates for fine chemistry.

P-chirogenic organophosphorus compounds

The &#x3b3;,&#x3b4;-unsaturated &#x3b1;-amino acids of general formula (I). Also, a versatile process for the stereospecific synthesis of said compounds of formula (I), involving a Wittig reaction. Further, intermediate products of general formulae (II) and (III), as shown below, which are involved in the synthesis of compounds (I). 

Versatile and stereospecific synthesis of &#x3b3;,&#x3b4;-unsaturated amino acids by Wittig reaction

Novel P-chirogenic organophosphorus compounds of general formula (I), a process for the synthesis of the compounds of formula (I), and intermediate products of general formulae (II), (III) and (IV), as shown below, are involved in the synthesis of compounds (I).  Metal complexes including compounds (I) as ligands are also described. The novel compounds and complexes are useful in asymmetric catalysis by transition metal complexes or organocatalysis, especially for asymmetric hydrogenation or allylation. Compounds of general formula (I) may be useful as agrochemical and therapeutic substances, or as reagents or intermediates for fine chemistry.

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Dijon, France

Jerome Bayardon