Hoffmann-la Roche Inc.

Jerome Anthony Iacobelli

Milan R Uskokovic

Bernard Michael Hennessy

Andrew D Batcho

Enrico G Baggiolini

Thomas A Narwid

Vitamin D3 analogs

The invention relates to a compound of the formula ##STR1## wherein A is ##STR2## Et is ethyl, and R is hydroxy and R.sup.1 is hydrogen or .dbd.CH.sub.2 or R is hydrogen or fluoro and R.sup.1 is .dbd.CH.sub.2. Compounds of formula I stimulate HL-60 cell differentiation. Accordingly, the compounds of formula I are useful as agents for the treatment of neoplastic diseases, such as leukemia.

16-ene-26,27-bishomo cholecalciferols

Compounds of the formula ##STR1## wherein R is hydrogen, fluorine, or hydroxyl, each R.sub.2 is lower alkyl or C(R.sub.3).sub.3 and R.sub.3 is halogen, X is .dbd.CH.sub.2 or when R is hydroxy, X is hydrogen or .dbd.CH.sub.2, and A is --C.tbd.C-- ##STR2## or --CH.sub.2 --CH.sub.2 --, which are useful in the treatment of hyperproliferative skin disorders, neoplastic diseases, and sebaceous gland diseases.

Vitamin D.sub.3 analogs

The invention relates to a compound of the formula ##STR1## wherein R is hydroxy and R.sup.1 is H.sub.2 or .dbd.CH.sub.2 or R is hydrogen or fluoro and R.sup.1 is .dbd.CH.sub.2 and (b) an inert carrier. Compounds of formula I are useful as agents for the treatment of hyperproliferative skin diseases, such as psoriasis, neoplastic diseases, such as leukemia, and sebaceous gland diseases, such as acne and sebhorreic dermatitis.

22-epimeric-1,25-dihydroxy-16,22,23-triene-cholecalciferol

A novel process for the preparation of 1.alpha.,25-dihydroxycholecalciferol and intermediates thereof is disclosed.

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Paramus, NJ, United States of America

Jerome Anthony Iacobelli