Hy2care B.v.

Chrn On-chip Biotechnologies B.v.

Universiteit Twente

Jeroen Christianus Hermanus Leijten

Tom Kamperman

Lisanne Paula Karbaat

Hermanus Bernadus Johannes Karperien

Pieter Jelle Dijkstra

Bram Zoetebier

Carlo Alberto Paggi

Séverine Le Gac

Bastien Venzac

Hermanus Bernardus Johannes Karperien

The invention provides a system comprising a microfluidic device for providing a mechanical stimulation to a material, the microfluidic device comprising a hosting chamber, a pressure array, and an elastic membrane, wherein the hosting chamber is configured for hosting the material, wherein the membrane is arranged between the pressure array and the hosting chamber, wherein the pressure array comprises a plurality of pressure chambers configured to independently provide a pressure to the membrane, wherein the pressure array comprises two adjacent pressure chambers sharing a chamber separator, wherein the membrane is configurable at a plurality of distances from the chamber separator based on pressures provided to the membrane by the two adjacent pressure chambers.

Microfluidic device for mechanically stimulating a material

A hydrogel particle that has an average cross-sectional diameter in the range from 1 micrometer (&#x3bc;m) to 1000 &#x3bc;m, wherein the particle includes a first polymer network with an average mesh size that allows diffusion of a molecule with an hydrodynamic radius of 1000 nanometer (nm) or less into the first polymer network and which particle includes one or more binding molecules that are immobilized by the polymer network. The hydrogel particle preferably has wherein the first polymer network has an average mesh size that prevents diffusion of a molecule with an average hydrodynamic radius of more than 1000 nm to diffuse into the first polymer network, preferably the mesh size prevents diffusion of a molecule with an average hydrodynamic radius of more than 100 nm, and preferably more than 5 nm. Methods for reducing the bioavailability of one or more soluble biological molecules in a biological system by using the described hydrogel particle.

Porous affinity hydrogel particles for reducing the bioavailability of selected biological molecules

Growing community of inventors

Enschede, Netherlands

Jeroen Christianus Hermanus Leijten