Stichting Dienst Landbouwkundig Onderzoek

Intervet International B.v.

Stichting Wageningen Research

Jeroen Alexander Kortekaas

Robertus Jacobus Maria Moormann

Paulus-Jozef Wichgers Schreur

Nadia Dimitrova Oreshkova

Rianka Petronella Maria Vloet

The invention relates to a bunyavirus, in which separated (NSm)Gn and Gc coding regions are functionally present on two different genome segments, preferably a bunyavirus that comprises a total of at least 4 genome segments. The invention further relates to methods for producing said bunyavirus, and to a composition comprising said bunyavirus and a suitable excipient.

Bunyaviruses with segmented glycoprotein precursor genes and methods for generating these viruses

The invention relates to methods of producing infectious bunyavirus replicon particles. These bunyavirus replicon particles are safe and can be used outside a biosafety containment. The invention further relates to recombinant bunyavirus replicon particles and uses of these recombinant bunyavirus replicon particles.

Methods to produce bunyavirus replicon particles

The invention relates to a recombinant classical swine fever virus (CSFV). A preferred recombinant CSFV comprises a deletion of at least one amino acid in a 'TAVSPTTLR' domain of the E2 protein. The invention further relates to a vaccine comprising the recombinant CSFV, a method for generating a recombinant CSFV, and use of a recombinant CSFV.

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Zwolle, Netherlands

Jeroen Alexander Kortekaas