Sandia Corporation

Unm Rainforest Innovations

Jerilyn A Timlin

Aaron Neumann

Matthew Graus

Jesse S Aaron

Methods and apparatus for rapid, culture free pathogen detection. The methods utilize optical spectroscopy techniques to identify and/or characterize pathogens in a sample via the detection of unique properties and/or analytes that are specific to particular pathogens.

Rapid culture free pathogen detection via spectrally resolved fluorescence microscopy

A hyperspectral stimulated emission depletion ('STED') microscope system for high-resolution imaging of samples labeled with multiple fluorophores (e.g., two to ten fluorophores). The hyperspectral STED microscope includes a light source, optical systems configured for generating an excitation light beam and a depletion light beam, optical systems configured for focusing the excitation and depletion light beams on a sample, and systems for collecting and processing data generated by interaction of the excitation and depletion light beams with the sample. Hyperspectral STED data may be analyzed using multivariate curve resolution analysis techniques to deconvolute emission from the multiple fluorophores. The hyperspectral STED microscope described herein can be used for multi-color, subdiffraction imaging of samples (e.g., materials and biological materials) and for analyzing a tissue by F&#xf6;rster Resonance Energy Transfer ('FRET').

Growing community of inventors

Albuquerque, NM, United States of America

Jerilyn A Timlin