Astrazeneca Ab

Cambridge Enterprise Limited

Jeremy Stephen Parker

Bharti Patel

Andrew Stocker

Paul Michael Murray

Philip Cornwall

Matthew James Welham

Paul Schofield

David Robert Spring

Melvyn Edward Giles

Jacob Robert James Perkins

Shelly Louise Jenkin

David Simon Ennis

Stephen James Walsh

Phillip Anthony Hopes

Hannah Fiona Sore

A conjugate comprising a protein or a peptide, a linker and an active agent, wherein the linker comprises the moiety of formula (III): (III) wherein two of A, Aand Aare N and the other of A, Aand Ais CH; X is selected from N, O and S, and Pep indicates where the moiety is linked to the protein or peptide, either directly or indirectly.

Linkers and conjugates

A process for making a compound of formula (I), which is useful as an intermediate to compounds which activate glucokinase, is described, (wherein P, Rand Rare as defined in the description).

Chemical process for the preparation of an amido-phenoxybenzoic acid compound

 A process for making a compound of formula (I), said process comprising a) reacting a compound of formula (II) with: i) a compound of formula (III) by nucleophilic aromatic substitution of Xand ii) a compound of formula (IV) for example by nucleophilic aromatic substitution b) where necessary, converting Xto a carboxylic acid; and c) coupling of the carboxylic acid group to an appropriate heterocyclic amine; wherein all variables are as defined in the description.

Process for making phenoxy benzamide compounds

A process for preparing a compound of formula (I) where Rand Rare as defined in the specification; and Ris hydrogen or a protecting group, which process comprises cyclisation of a compound of formula (II) where R, Rand Rare as defined in relation to formula (I), and Ris nitrogen-protecting group, and removing the group R&#x2014;, and thereafter if desired or necessary, removing any protecting group Rto obtain the corresponding carboxylic acid. Novel intermediates and the use of the products in the preparation of pharmaceutical compounds is also described and claimed. 

Process and intermediates for the preparation of the thienopyrrole derivatives

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Bristol, United Kingdom

Jeremy Stephen Parker