Terumo Bct, Inc.

Caridianbct, Inc.

Rainglobes, LLC

Jeremy P Kolenbrander

James R Ladtkow

Jeffrey A Steward

Joseph A Scibona

William Sweat

Lee F Carter

Chris Fletcher

Geoffrey M Uhl

Briden Ray Stanton

Christopher Fletcher

John R Lindner

Joshua James

Lawrence Scott Larson

James Ladtkow

Aditya Dalvi

Brian M Holmes

Thomas J Felt

John R Linder

Fred Northup

William G Palsulich

Jennifer Hinz

Frederick Bowen Northup, Jr

Charles Patrick Mangan

Dave Tyler

Dave Gibbons

Joseph Scibona

Jennifer Wheeler

Described are embodiments that include methods and devices for separating composite liquids into components. Embodiments involve the use of a flexible membrane for separating a composite liquid into components. The composite liquid may include, in embodiments, a cellular containing liquid, such as whole blood or components of whole blood. In one specific embodiment, the composite liquid is a buffy coat.

Separating composite liquids

A centrifugal blood separation system comprising a rotor, a light source, an optical sensor, a control system, a separation vessel, and an optical cell on the separation vessel. The optical cell has a first extraction port extending radially outwardly into the optical cell, a red blood cell extraction port downstream from the first extraction port and extending into the optical cell beyond the first extraction port; and a dam between said first extraction port and said red blood cell extraction port, having an upper edge and a lower edge, wherein the first extraction port and the red cell extraction port are radially between the upper edge and the lower edge of the dam. Also, a first extraction port having a bore having a first diameter, a lumen having a second diameter smaller than the first diameter, and a frustro-conical passageway coupling the bore to the lumen.

System for blood separation with shielded extraction port and optical control

A disposable blood separation set and a centrifugal blood processing system comprising a blood processing chamber adapted to be mounted on a rotor of a centrifuge; a frustro-conical cell separation chamber in fluid communication with the processing chamber, the cell separation chamber having an inlet, an outlet and a gravity valve inside the cell separation chamber. The valve is responsive to the gravitational field created by the speed of the rotor. When the rotor spins at high speed, the gravity valve may open the outlet at a location proximal to an axis of rotation of the rotor. When the rotor spins at a lower speed, the gravity valve may open the outlet at a location distal from the axis.

System for blood separation with a separation chamber having an internal gravity valve

A dioramic apparatus includes a vessel having an inferior portion and a superior portion. The vessel includes a shell and defines an interior space. The interior space is partially filled by a liquid medium. At least one dioramic scene is disposed in the interior space. A reservoir is in fluid communication with the interior space. The reservoir includes a flow plate defining at least one liquid intake and at least one liquid output port. The at least one liquid intake is configured and arranged for receiving at least a portion of the liquid medium from the interior space when the dioramic apparatus is at least partially inverted. The at least one liquid output port is configured and arranged to output at least a portion of the liquid medium from the reservoir when the vessel is placed in an upright position.

Device for creating and displaying liquid-medium movement within a vessel containing a dioramic scene

A centrifuge for separating blood having a camera observing fluid flow, and a controller controlling the flow. The location of an interface is detected by image processing steps, which may comprise the steps of 'spoiling' the image, 'diffusing' the image, &#x201c;edge detection&#x201d;, &#x201c;edge linking&#x201d;, &#x201c;region-based confirmation&#x201d;, and &#x201c;interface calculation&#x201d;. &#x201c;Spoiling&#x201d; reduces the number of pixels to be examined preferentially on orthogonal axis oriented with respect to the expected location of the interface or phase boundary. &#x201c;Diffusing&#x201d; smoothes out small oscillations in the interface boundary, making the location of the interface more distinct. &#x201c;Edge detection&#x201d; computes the rate of change in pixel intensity. &#x201c;Edge linking&#x201d; connects adjacent maxima. &#x201c;Region-based confirmation&#x201d; creates a pseudo image of the regions that qualify as distinct. &#x201c;Final edge calculation&#x201d; uses the points where the shade changes in the pseudo image, averages the radial displacement of these points for the interface position.

Blood processing apparatus with robust automated process control

A centrifuge for separating blood having a camera observing fluid flow, and a controller controlling the flow. The location of an interface is detected by image processing steps, which may comprise the steps of 'spoiling' the image, 'diffusing' the image, &#x201c;edge detection&#x201d;, &#x201c;edge linking&#x201d;, &#x201c;region-based confirmation&#x201d;, and &#x201c;interface calculation&#x201d;. &#x201c;Spoiling&#x201d; reduces the number of pixels to be examined preferentially on orthogonal axis oriented with respect to the expected location of the interface or phase boundary. &#x201c;Diffusing&#x201d; smoothes out small oscillations in the interface boundary, making to the location of the interface more distinct. &#x201c;Edge detection&#x201d; computes the rate of change in pixel intensity. &#x201c;Edge linking&#x201d; connects adjacent maxima. &#x201c;Region-based confirmation&#x201d; creates a pseudo image of the regions that qualify as distinct. &#x201c;Final edge calculation&#x201d; uses the points where the shade changes in the pseudo image, averages the radial displacement of these points for the interface position.

A centrifuge for separating blood having a camera observing fluid flow, and a controller controlling the flow. The location of an interface is detected by image processing steps, which may comprise the steps of 'spoiling' the image, 'diffusing' the image, &#x201c;edge detection&#x201d;, &#x201c;edge linking&#x201d;, &#x201c;region-based confirmation&#x201d;, and &#x201c;interface calculation&#x201d;. &#x201c;Spoiling&#x201d; reduces the number of pixels to be examined preferentially on orthogonal axis oriented with respect to the expected location of the interface or phase boundary. &#x201c;Diffusing&#x201d; smoothes out small oscillations in the interface boundary, making the location of the interface more distinct. &#x201c;Edge detection&#x201d; computes the rate of change in pixel intensity, or. &#x201c;Edge linking&#x201d; connects adjacent maxima. &#x201c;Region-based confirmation&#x201d; creates a pseudo image of the regions that qualify as distinct. &#x201c;Final edge calculation&#x201d; uses the points where the shade changes in the pseudo image, averages the radial displacement of these points for the interface position.

A blood cell collection system having means for detecting when a cell separation chamber has filled with white blood cells, and flushing the cells out of the cell separation chamber into a collect bag. A red-green sensor senses the optical characteristics of fluid leaving the cell separation chamber. A baseline value is calculated. The device calculates a ratio of the intensities of red light and green light and a peak-to-peak ratio of intensities. If either ratio exceeds thresholds computed from the baseline, the device flushes the cells into the collect bag. A camera detects white cells passing into the cell separation chamber and the device calculates the number of cells being collected. If the calculated number of collected cells exceeds a certain limit, the cell separation chamber is flushed. If the device is unable to establish a baseline, the donation can proceed, relying solely on the calculated number of collected cells.

Blood processing apparatus with controlled cell capture chamber trigger

A centrifugal blood separation apparatus having an optical camera control system with a focused, stationary light source. A diffusion plate mounted on a rotor, rather than on or near the light source, allows an intense light beam to be transmitted from the light source to the rotor and then diffused at the rotor across an observation region. Different characteristics of a diffusion surface allow different lighting regions within the observation region. The diffusion plate has upper and lower plates with a diffusion surface sealed between the plates. This prevents degradation or contamination of the diffusion surface by abrasion, dirt, blood components or other materials that might incidentally contact the diffusion surface.

Blood processing apparatus with sealed diffuser in optical control apparatus

The invention relates generally to methods of monitoring and controlling the processing of blood and blood samples, particularly the separation of blood and blood samples into its components with a two-dimensional optical measurement and control device. The method may comprise the steps of providing a blood processing system comprising a density centrifuge blood processing system and an elutriation blood processing system; filling the elutriation blood processing system with a desired component; measuring a cellular flux of cells entering the elutriation blood processing system with a two-dimensional optical control system; and flushing the elutriation blood processing system.

Growing community of inventors

Brighton, CO, United States of America

Jeremy P Kolenbrander