Clemson University

Orthovita, Inc.

Jeremy J Mercuri

Dan T Simionescu

Richard diMonda

Matt Pursley

Alice Bachert

Alison Santillo

Brian Curtis Keim

Rachel McGuire

Ryan Borem

Michael David Stokes

Nicholas Freeman

Christopher Fernandez

Adam Marrocco

Alan Michael Marionneaux

George Marion Seignious, Iv

Steven Brian Singleton

Ishmael Bentley

Integratable treatment devices, assemblies including a treatment device, at least one anchor, and a tether coupled thereto, and various methods and devices for inserting such devices and assemblies are disclosed herein. The treatment devices can be made of an integratable material that is not fully bioresorbable but promotes native tissue growth in and around the material. Certain methods involve first inserting at least one anchor and then advancing a treatment device via a tether coupled to the at least one anchor. Further various insertion devices that can be used to implant any of the treatment devices herein using any of the methods herein are disclosed.

Annulus repair devices, systems, and methods

A medical positioning bracket is described that provides users with the ability to attach and secure multiple bone tunnel drill guides into a single working unit. Users can manipulate each drill guide independently and lock the drill guides at desired locations relative to one another to achieve precise bone tunnel angles and locations.

Positioning bracket for multiple bone tunnel drill guides

Biocompatible biomimetic materials that exhibit desirable mechanical properties while also encouraging cell ingrowth and proliferation are described. The biomaterials include a multi-layer laminate of three or more decellularized aligned collagen tissues. The individual layers are aligned with one another in an angle-ply arrangement, with the collagen of each layer aligned at an angle to the collagen of the adjacent layer. The biomaterials are useful as collagenous graft materials such as a patch for a hernia in an annulus fibrosus or grafting materials for repair of tendons, ligaments, cartilage and other musculoskeletal tissues.

Multi-layered biomimetic material and method of formation

Methods for developing a decellularized tissue and biomaterials for use as biomimetic grafts or in vitro cellular scaffolds formed with the decellularized tissue are described. The biomaterials are particularly well suited for use as an intervertebral disc graft. The decellularized tissue is formed from an intervertebral disc source tissue and can be substantially decellularized and substantially free of potential immunogenic material (e.g., DNA and RNA), while maintaining ECM materials including both glycosaminoglycan and collagen.

Decellularized biomaterial and method for formation

The present invention relates to a flowable bone graft material including an inorganic composition comprising calcium phosphate having a particle size of about 100 &#x3bc;m to about 1,000 &#x3bc;m, bioactive glass, and one or more biocompatible polymers comprising carboxymethyl cellulose and a fluid.

Bioactive flowable wash-out resistant bone graft material and method for production thereof

A hydrogel biomaterial that can be utilized as a nucleus pulposus replacement material is described. The hydrogel biomaterial can is an elastin-glycosaminoglycan-collagen composite hydrogel biomaterial that can mimic the biochemical and functional characteristics of the human nucleus pulposus. Methods for forming the hydrogel biomaterial are also described as are methods for use of the hydrogel biomaterial, one of which is as an in vivo nucleus pulposus replacement material, another of which is a scaffolding material for use in nucleus pulposus tissue engineering applications.

Shape-memory sponge hydrogel biomaterial

A nucleus pulposus replacement is described that includes a containment balloon that can sequester synthetic and/or tissue engineered fill material(s) in the nucleus pulposus region of the IVD thus mitigating migration and expulsion of the fill materials. The containment balloon can be formed of a biocompatible material that includes the structural proteins elastin and collagen. The containment balloon is joined to a closure device that can be used to deliver a fill material, e.g., a hydrogel, to the interior of the containment balloon following implantation of the replacement device in the intervertebral disc area.

Growing community of inventors

Easley, SC, United States of America

Jeremy J Mercuri