Biogen Ma Inc.

Jeremy Duffield

Joseph P Lyssikatos

Gnanasambandam Kumaravel

Kevin Guckian

Jermaine Thomas

Brian Stuart Lucas

Tracy J Jenkins

Timothy Raymond Chan

Robert Meissner

Irina Leaf

Jeffery Vessels

Jeffrey Vessels

Nathan Genung

Provided are compounds of Formula I, or pharmaceutically acceptable salts thereof, and methods for their use and production. Formula (I) The compounds are IRAK-4 inhibitors useful for treating an inflammatory disease, an autoimmune disease, cancer, a cardiovascular disease, a disease of the central nervous system, a disease of the skin, an ophthalmic disease and condition, and a bone disease. 

IRAK4 inhibiting agents

Provided are compounds of Formula I, or pharmaceutically acceptable salts thereof, and methods for their use and production.

Provided are compounds of Formula (I), or pharmaceutically acceptable salts thereof, and methods for their use and production.

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Cambridge, MA, United States of America

Jeremy Duffield