Northwestern University

Northshore University Healthsystem

American Biooptics, LLC

Jeremy D Rogers

Vadim Backman

Hariharan Subramanian

Hemant Kumar Roy

Bradley Gould

Nikhil N Mutyal

Vladimir Turzhitsky

Andrew J Radosevich

John E Chandler

Craig White

Lusik Cherkezyan

Young L Kim

The Quyen Nguyen

Brand Randall

Yang Liu

Hermant Roy

Low-coherence enhanced backscattering (LEBS) spectroscopy is an angular resolved backscattering technique that is sensitive to sub-diffusion light transport length scales in which information about the scattering phase function is preserved. Lens-based and lens-free fiber optic LEBS probes are described that are capable of measuring optical properties of a target tissue through depth-limited measurements of backscattering angles within the enhanced backscattered cone.

Probe apparatus for measuring depth-limited properties with low-coherence enhanced backscattering

The present technology provides methods, systems, and apparatuses to achieve high throughput and high speed acquisition of partial wave spectroscopic (PWS) microscopic images. In particular, provided herein are high-throughput, automated partial wave spectroscopy (HT/A-PWS) instruments and systems capable of rapid acquisition of PWS Microscopic images and clinical, diagnostic, and research applications thereof.

High throughput partial wave spectroscopic microscopy and associated systems and methods

Systems, methods, and apparatuses of elastic light scattering spectroscopy and low-coherence enhanced backscattering spectroscopy are described here. An apparatus couple-able to a light source and a target object, to facilitate light transmission between the light source and the target object, the apparatus comprises: a probe to emit incident light that is partially coherent obtained from the light source onto the target object and to receive interacted light, the interacted light to be backscattered light from illumination of the incident light on the target object, the probe comprising: a delivery channel having at least one delivery optical fiber with a distal end portion couple-able to the light source and a proximal end portion suited to couple the incident light to the target object, a collection channel having a first collection optical fiber suited to collect substantially co-polarized backscattered light and a second collection optical fiber suited to collect substantially cross-polarized backscattered light.

Systems, methods and apparatuses of elastic light scattering spectroscopy and low coherence enhanced backscattering spectroscopy

Systems, methods, and apparatuses of low-coherence enhanced backscattering spectroscopy are described within this application. One embodiment includes providing incident light comprising at least one spectral component having low coherence, wherein the incident light is to be illuminated on a target object in vivo. An intensity of one or more of at least one spectral component and at least one angular component of backscattering angle of backscattered light is recorded, wherein the backscattered light is to be backscattered from illumination of the incident light on the target object and wherein the backscattering angle is an angle between incident light propagation direction and backscattered light propagation direction. The intensity of the at least one spectral component and the at least one backscattering angle of backscattered light is analyzed, to obtain one or more optical markers of the backscattered light, toward evaluating said properties.

Systems, methods, and apparatuses of low-coherence enhanced backscattering spectroscopy

Growing community of inventors

Madison, WI, United States of America

Jeremy D Rogers