Merck Sharp + Dohme Corp.

Southern Research Institute

Gilead Pharmasset LLC

Other

Roche Palo Alto LLC

Pharmasset, Inc.

Jeremy Clark

Neng-Yang Shih

F George Njoroge

John J Piwinski

John A Secrist, Iii

Subramaniam Ananthan

Joseph A Maddry

Feng Geng

Robert C Reynolds

Hollis S Kezar, Iii

Cecil D Kwong

Abhijit Roychowdhury

Frank W Bennett

Ashok Arasappan

Anita T Fowler

Peiyuan Wang

Srikanth Venkatraman

Jinfa Du

Byoung-Kwon Chun

Vinay M Girijavallabhan

Junxing Shi

Keshab Sarma

Francisco Velazquez

Vishal Verma

Yuhua Huang

Regina Huelgas

John A Secrist

Hollis S Kezar

Iii Hollis S Kezar

Iii John A Secrist

Wojciech Kolonia Wola Zaradzynski Stec

The disclosed invention provides compositions and methods of treating a Flaviviridae infection, including hepatitis C virus, West Nile Virus, yellow fever virus, and a rhinovirus infection in a host, including animals, and especially humans, using a (2'R)-2&#x2032;-deoxy-2&#x2032;-fluoro-2&#x2032;-C-methyl nucleosides, or a pharmaceutically acceptable salt or prodrug thereof.

Modified fluorinated nucleoside analogues

The present invention provides compounds of Formula (A): (Chemical formula should be inserted here as it appears on abstract in paper form) (A) and tautomers, isomers, and esters of said compounds, and pharmaceutically acceptable salts, solvates, and prodrugs of said compounds, wherein wherein each of R, R, X, Y, Z, R, R, R, R, R, R, R, R, R, R, R, R, and n is selected independently and as defined herein. Compositions comprising such compounds are also provided. The compounds of the invention are effective as inhibitors of HCV, and are useful, alone and together with other therapeutic agents, in treating or preventing diseases or disorders such as viral infections and virus-related disorders. 

Ethenyl-substituted pyridine and pyrimidine derivatives and their use in treating viral infections

The present invention provides compounds of Formula (I): and tautomers, isomers, and esters of said compounds, and pharmaceutically acceptable salts, solvates, and prodrugs of said compounds, wherein each of R, R, X, Y, Z, R, R, R, R, R, R, R, R, R, Rand n is selected independently and as defined herein. Compositions comprising such compounds are also provided. The compounds of the invention are effective as inhibitors of HCV, and are useful, alone and together with other therapeutic agents, in treating or preventing diseases or disorders such as viral infections and virus-related disorders. 

Substituted pyridine and pyrimidine derivatives and their use in treating viral infections

The present invention provides compounds of Formula (I): and tautomers, isomers, and esters of said compounds, and pharmaceutically acceptable salts, solvates, and pro-drugs of said compounds, wherein each of R, R, X, Y, Z, R, R, R, R, R, R, R, R, R, Rand n is selected independently and as defined herein. Compositions comprising such compounds are also provided. The compounds of the invention are effective as inhibitors of HCV, and are useful, alone and together with other therapeutic agents, in treating or preventing diseases or disorders such as viral infections and virus-related disorders.

Ethynyl-substituted pyridine and pyrimidine derivatives and their use in treating viral infections

A system and method for producing realistic backgrounds in studio photography is provided. The system comprises a background screen lit from behind by a light source. The background screen comprises a graphic screen upon which a high resolution image is printed. A filter screen behind the graphic screen is positioned substantially parallel to the graphic screen and separated from the graphic screen by a predetermined distance. The photography subject is placed in front of the graphic screen and pictures are taken. The diffusion of light through the filter screen onto the graphic screen results in highly realistic background images.

Backlit photography background system and method

Compounds having the formula I wherein Ris as herein defined are Hepatitis C virus NS5b polymerase inhibitors. Also disclosed are compositions and methods for inhibiting hepatitis replication, and processes for making the compounds of formula I 

Antiviral nucleosides

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Birmingham, AL, United States of America

Jeremy Clark