Sri International

Jeremiah Malerich

Nathan Collins

Peter Madrid

Brian Keith McCoy

Kevin Luebke

Jason D White

Bryan Glaser

Markus Krummenacker

Judy Szeto

Mario Latendresse

Joseph A Kozocas

Kristina Rucker

Brian K Mccoy

Retrosynthetic methods are described for determining one or more optimal synthetic routes to generate a target compound.

Computational generation of chemical synthesis routes and methods

Embodiments in accordance with the present disclosure are directed to apparatuses used for reaction screening and optimization purposes. An example apparatus includes a plurality of reaction vessels, a dispensing subsystem, at least one reactor module, an analysis subsystem, an automation subsystem, and control circuitry. The dispensing subsystem delivers reagents to the plurality of reaction vessels for a plurality of reaction mixtures having varied reaction conditions. The at least one reactor module drives a plurality of reactions within the plurality of reaction vessels. The analysis subsystem analyzes compositions contained in the plurality of reaction vessels. The automation subsystem selectively moves the plurality of reaction vessels from a location proximal to the dispensing subsystem to the at least one reactor module based on experimental design parameters. And, the control circuitry identifies optimum reaction conditions for a target end product based on the analysis.

Apparatuses for reaction screening and optimization, and methods thereof

This disclosure generally relates to methods of making ibuprofen, naproxen, and derivatives thereof. This disclosure also generally relates to compounds made by the disclosed methods. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

Continuous flow synthesis of ibuprofen

An aminocoumarin conjugated to a fluorescent label through a secondary amine, is operative as a fluorescent polarization probe of the DNA gyrase B or topoisomerase IV E subunit. The probe is used for detecting topoisomerase inhibitor binding by fluorescence polarization, particularly in a high-through put topoisomerase inhibitor assay.

Topoisomerase binding probe and method of use

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San Francisco, CA, United States of America

Jeremiah Malerich