Massachusetts Institute of Technology

Samsung Electronics Co., Ltd.

Living Proof, Inc.

Dana-farber-cancer Institute Inc.

University of Nebraska

Dow Silicones Corporation

Jeremiah Allen Johnson

Wenxu Zhang

Hung Vanthanh Nguyen

Yivan Jiang

Yang Shao-Horn

Mao Chen

Mingjun Huang

Peyton Shieh

Shuting Feng

Aleksandr V Zhukhovitskiy

Farrukh Vohidov

Longyan Liao

Livia Giordano

Soo-Young Kang

Zhaoxia Ji

Dinara A Villanueva

Ken Kawamoto

Sara Ann Johnson

Jonathan Christopher Barnes

Nolan Gallagher

Keith Husted

Robinson Anandakathir

Niels Holten-Andersen

Scott Charles Grindy

Qixian Chen

Deborah June Choi Ehrlich

Nawodi Abeyrathna

Samantha Lynn Kristufek

Yoshiki Shibuya

Taeyoung Kim

Bizhong Zhu

Hyukjae Kwon

Dongjoon Lee

Mokwon Kim

Irene M Ghobrial

Kaila M Mattson

Andrzej Rajca

Bin Liu

Michelle MacLeod

Angela Xiaodi Gao

Xu Qin

Valerie Lensch

Yutong Dai

Landon Kilgallon

Wencong Wang

Megan Hill

Matthew R Golder

Sipei Li

Jeffrey Lopez

Teruhiko Saito

Christopher M Brown

Mingjiang Zhong

Alexandre Detappe

Michael Agius

XueZhou Wang

Elisabeth Prince

Leticia C Cardoso Da Costa

Alexandra Johnson

Yufeng Wang

The present disclosure provides, in some aspects, macromonomers of Formula (I), and salts thereof; methods of preparing the macromonomers, and salts thereof; Brush prodrugs (polymers); methods of preparing the Brush prodrugs; compounds of Formula (II); conjugates of Formula (III), and salts thereof; pharmaceutical compositions comprising a Brush prodrug, or a conjugate or a salt thereof; kits comprising: a macromonomer or a salt thereof, a Brush prodrug, a compound, a conjugate or a salt thereof, or a pharmaceutical composition; methods of using the Brush prodrugs, or conjugates or salts thereof; and uses of the Brush prodrugs, and conjugates or salts thereof. These chemical entities may be useful in delivering pharmaceutical agents to a subject or cell.

Brush prodrugs and uses thereof

The present disclosure provides solid-state electrolytes based on a borylated-polymers (e.g., borylated-polybutadiene). Further provided are kits comprising, methods of synthesizing, and methods of using the solid-state electrolytes. In some aspects, the solid-state electrolytes demonstrate high ion conductivity at room temperature.

Polymer electrolytes for electrochemical cells

The present invention provides polymer compositions for use in cosmetic nail polish compositions. More particularly, the present disclosure relates to the introduction of cleavable comonomer additives into an existing polymer composition to produce a chemically deconstructable composition. Methods and compositions for removing the nail polish composition are also disclosed.

Cleavable comonomer strategy for accelerating removal of gel nail polish

The present disclosure describes functional oligomers or functional polymers. The functional oligomers or functional polymers may contain functional groups, e.g., —OH and/or —CHO. The functional oligomers or functional polymers may be obtained from hydrolyzing certain copolymers and may be soluble in commercially available solvents. The copolymers may be thermosetting polymers. The functional oligomers and functional polymers may be useful for recycling thermosetting polymers and may be useful as starting materials for preparing additional oligomers or polymers.

Functional oligomers and functional polymers including hydroxylated polymers and conjugates thereof and uses thereof

A networked silicone is disclosed. The networked silicone comprises crosslinked strands of looped organosilicon compounds. A composition for preparing the networked silicone is also disclosed, and comprises (A) a looped organosilicon compound, (B) a crosslinking organosilicon compound, and optionally (C) a catalyst. Additionally, a method of preparing the networked silicone is disclosed, and comprises reacting the looped organosilicon compound (A) and the crosslinking organosilicon compound (B), optionally in the presence of the catalyst (C), to give the networked silicone. A reaction product comprising the networked silicone is also disclosed. The reaction product is prepared from the composition and/or in accordance with the method, and may be a cured product. Additionally, a composite article and a method of forming the same are disclosed. The composite article is formed by disposing a networked silicone composition on the substrate and curing the networked silicone composition, thereby preparing the composite article.

Networked silicones and related compositions, methods, and compounds

A class of sulfonimide salts for solid-state electrolytes can be synthesized based on successive SAr reactions of fluorinated phenyl sulfonimides: Fluorinated Aryl Sulfonimide Tags (FAST). The chemical and electrochemical oxidative stability of these FAST salts as well as other properties like solubility, Lewis basicity, and conductivity can be tuned by introducing different numbers and types of nucleophilic functional groups to the FAST salt scaffold.

Sulfonimide salts for battery applications

Disclosed are methods, compositions, reagents, systems, and kits to prepare and utilize branched multi-functional macromonomers, which contain a ring-opening metathesis polymerizable norbornene group, one or more reactive sites capable of undergoing click chemistry, and a terminal acyl group capable of undergoing a coupling reaction; branched multi-cargo macromonomers; and the corresponding polymers are disclosed herein. Various embodiments show that the macromonomers and polymers disclosed herein display unprecedented control of cargo loading of agents. These materials have the potential to be utilized for the treatment of diseases and conditions such as cancer and hypertension.

Branched multi-functional macromonomers and related polymers and uses thereof

The present disclosure provides enynes, end-functionalized polymers, conjugates, methods of preparation, compositions, kits, and methods of use. The conjugates comprise at least (1) a peptide (e.g., an antibody), protein, nucleoprotein, mucoprotein, lipoprotein, glycoprotein, or polynucleotide; and (2) a polymer comprising a pharmaceutical agent. The conjugates may be useful in delivering (e.g., targeted delivering) the pharmaceutical agent to a subject in need thereof or cell or treating, preventing, or diagnosing a disease.

Biomolecule-polymer-pharmaceutical agent conjugates for delivering the pharmaceutical agent

Disclosed multifunctional compounds, conjugates, macromolecules, and polymers that target dysregulated proteins for degradation. Also disclosed are methods of preparation, compositions, kits, and methods of use relating to the degraders.

Proteolysis targeting chimeric molecules (PROTACs) with functional handles and uses thereof

The present disclosure provides compositions comprising:

Reprocessable compositions

The present disclosure provides cyclic silyl ethers of the formula: and salts thereof. The cyclic silyl ethers may be useful as monomers for preparing polymers. Also described herein are polymers prepared by polymerizing a cyclic silyl ether and optionally one or more additional monomers. The polymers may be degradable (e.g., biodegradable). One or more O—Si bonds of the polymers may be the degradation sites. Also described herein are compositions and kits including the cyclic silyl ethers or polymers; methods of preparing the polymers; and methods of using the polymers, compositions, and kits.

Degradable polymers of a cyclic silyl ether and uses thereof

Materials (e.g., particles, hydrogels) that provide extended release of one or more therapeutic agents are useful platforms for drug delivery. In part, the present invention relates to new triblock (ABC) bottlebrush copolymers which can be used in the formulation of particles and hydrogels for the extended release of therapeutic agents. In certain embodiments, the triblock bottlebrush copolymers, particles, and hydrogels described herein are thermally-responsive and gel at physiological temperature (e.g., upon administration to a subject), providing injectable and/or implantable gels which can be used for extended release drug delivery. The present invention also provides methods for extended release drug delivery, and methods of treating and/or preventing a disease or conditions in a subject, using the inventive copolymers, particles, and hydrogels. In addition, the present invention provides methods of preparing the triblock bottlebrush copolymers described herein.

Bottlebrush copolymers and uses thereof

Disclosed are methods, compositions, reagents, systems, and kits to prepare nitroxide-functionalized brush-arm star polymer organic radical contrast agent (BASP-ORCA) as well as compositions and uses thereof. Various embodiments show that BASP-ORCA display unprecedented per-nitroxide and per-molecule transverse relaxivities for organic radical contrast agents, exceptional stability, high water solubility, low in vitro and in vivo toxicity, and long blood compartment half-life. These materials have the potential to be adopted for tumor imaging using clinical high-fieldH MRI techniques.

Brush-arm star polymer imaging agents and uses thereof

Growing community of inventors

Boston, MA, United States of America

Jeremiah Allen Johnson