Nycomed Salutar, Inc.

Catalytica, Inc.

The Dow Chemical Company

Catalytica Associates, Inc.

The University of British Columbia

Other

University of Iowa Research Foundation

Symyx Technologies, Inc.

Symyx Solutions, Inc.

Jere D Fellmann

Paul R Wentrcek

Robert James Saxton

Martha Garrity

Janis Vasilevskis

Alan D Watson

John Varadarajan

Jacques C De Deken

Joan F Carvalho

Peter H Kilner

Lyubov S Kipnis

Isy Goldwasser

Philip E Garrou

Horst G Langer

Chris Orvig

John H McNeill

David R Dorsett, Jr

Hamid R Hoveyda

Gandara Amarasinghe

Paul Tung

Louis Messerle

Brian Campion

Larry Margerum

Ying Zhou

Jo Klaveness

Eric G Derouane

Dietmar Seyferth

Gene Curtis Jamieson

Stanley F Newman

Michael Koo

Howard P Withers, Jr

Pascale Massiani

Phat T Lu

Nils B Vogt

Michael David Koo

Lawrence Margerum

Methods, apparatus, and business processes enabling individual chemists to design, order, and obtain data for multiple experiments or measurements in a timely and cost-effective manner. In particular implementations, the invention includes methods and apparatus for designing sets of custom experiments, ordering the execution of the experiments, communicating the order to a remote laboratory, executing the experiments at that laboratory using high-throughput technologies, and communicating the experimental results to the user.

Remote execution of materials library designs

Remote Execution of Materials Library Designs

Aziridines may be subjeted to a cyclooligomerization reaction to produce polyazacycloalkane compounds useful for example in the preparation of chelating agents for use in diagnostic imaging contrast agents. N-benzyl-aziridine in particular is useful as it can be cyclotetramerized and debenzylated to yield cyclen, a key intermediate in chelating agent preparation. The invention provides a particularly attractive route to production of N-benzyl and other N-arylmethyl aziridines of formula (I)

Preparation of n-arylmethyl aziridine derivatives, 1,4,7,10-tetraazacyclododecane derivatives obtained therefrom and n-arylethyl-ethanolamine sulphonate esters as intermediates

Preparation of N-arylmethyl aziridine derivatives,

Biodegradable blood-pool contrast agents

Metabolically cleavable dendrimeric polychelants

This invention relates to dichelants, in particular compounds having two macrocyclic chelant groups linked by a bridge containing an ester or amide bond, especially compounds of formula Vb ##STR1## (wherein each X which may be the same or different is NZ, O or S, at least two Xs being NZ;

Dichelants

Dendrimeric compounds

There are provided vanadium compositions for use in the treatment of hypertension, obesity and diabetes, in particular improved oral compositions comprising oxovanadium (IV) chelates of monoprotic, bidentate oxygen, oxygen and oxygen, nitrogen coordinating ligands especially kojic acid and maltol.

Method of suppressing appetite with vanadium complexes

Use of fullerenes in diagnostic and/or therapeutic agents

Macrocyclic polyaza dichelates linked through ring nitrogens via an

Methods of treating hypertension with vanadium compositions

Selective sorption of dialkylated multinuclear aromatic compounds

A process for the manufacture of resorcinol is described which relies upon the intermediacy of a .alpha.,.beta.-unsaturated ketone which can be reacted with a hydroxy moiety-containing compound to obtain a resorcinol precursor which is subsequently converted to resorcinol. In a specific embodiment, 2-cyclohexenone is reacted with water to obtain 3-hydroxycyclohexanone which is dehydrogenated to resorcinol. In another embodiment, 2-cyclohexenone is oxidized to cyclohexane-1,3-dione which is dehydragenated obtain resorcinol.

Process for manufacture of resorcinol

The selective isopropylation of biphenyl or 4-isopropylbiphenyl to diisopropylbiphenyl while maximizing the yield of the 4,4'-diisopropoylbiphenyl isomer is achieved by carrying out the reaction in the presence of an acidic crystalline molecular sieve with pore aperture 5.7-6.1 .ANG., preferably SAPO-11 or ZSM-12.

Manufacture of 4,4'-diisopropylbiphenyl

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Livermore, CA, United States of America

Jere D Fellmann