Abbvie Inc.

Jeorg Rosenberg

Laman L Alani

Gunther Berndl

Bernd Liepold

Soumojeet Ghosh

Ulrich Reinhold

Joerg Breitenbach

A solid pharmaceutical dosage form providing improved oral bioavailability is disclosed for inhibitors of HIV protease. In particular, the dosage form comprises a solid dispersion of at least one HIV protease inhibitor and at least one pharmaceutically acceptable water-soluble polymer and at least one pharmaceutically acceptable surfactant, said pharmaceutically acceptable water-soluble polymer having a Tg of at least about 50&#xb0; C. Preferably, the pharmaceutically acceptable surfactant has an HLB value of from about 4 to about 10.

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Ellerstadt, Germany

Jeorg Rosenberg