Institut Pasteur Korea

Qurient Co., Ltd.

Lead Discovery Center Gmbh

Qli5 Therapeutics Ag

Jeongjea Seo

Uwe Koch

Jung Yoon Kim

Sangchul Lee

Jaeseung Kim

Peter Nussbaumer

Kiyean Nam

Bert Klebl

Axel Choidas

Sunhee Kang

Dongsik Park

SaeYeon Lee

Mooyoung Seo

Yeejin Jeon

Min Jung Seo

Jeongjun Kim

Gahee Choi

Sung-Jun Han

Juhee Kang

Young-In Yang

Doohyung Lee

Seohyun Ahn

Anke Unger

Sumi Lee

Jiye Ahn

Minjung Seo

Yunmi Lee

Robert Huber

Jung Hwan Kim

Ryang Yeo Kim

Wongyun Ahn

Seung-Joo Lee

Julian Engel

Kevin Pethe

Soohyun Oh

Carsten Degenhart

The present invention relates to benzimidazole derivatives having the general formula I, wherein n is 0 or 1; Xand Xare independently, at each occurrence, CRor N; Y is C-Calkylene, wherein alkylene is optionally substituted with one to two C-Calkyl groups; Ris selected from the group consisting of hydrogen, halogen, C-Calkoxy, &#x2014;NH, &#x2014;NHR, &#x2014;NRRand &#x2014;NH&#x2014;(R)&#x2014;R, n being 0 or 1; Ris selected from the group consisting of hydrogen, halogen, C-Calkyl, &#x2014;NH, &#x2014;NHR, &#x2014;NRRand &#x2014;NH&#x2014;(R)&#x2014;R; Ris selected from the group consisting of hydrogen, hydroxyl, OR, &#x2014;NRR, C-Calkoxy, C-Calkyl, C-Ccycloalkyl, C-Chaloalkyl, &#x2014;C(O)NHR, aryl, heteroaryl and heterocyclyl, wherein each of said cycloalkyl, aryl, heteroaryl and heterocyclyl is optionally and independently substituted with one to four Rgroups; and Ris selected from the group consisting of &#x2014;NH, &#x2014;N(R)(V)R, &#x2014;NH(V)&#x2014;OR, &#x2014;NHC(O)R, and groups of formula 1a shown below, and their use in the treatment of diseases, in particular inflammatory diseases, cancer, stroke and/or Alzheimer's disease. 

2-amino-benzimidazole derivatives and their use as 5-lipoxygenase and/or prostaglandin E synthase inhibitors

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Seoul, South Korea

Jeongjea Seo