Daewoong Pharmaceutical Co., Ltd.

Jeong-Taek Shin

Jeong-Hyun Son

Deok Ki Eom

Bong-Yong Lee

Seung Chul Lee

Chun Ho Lee

Hee-kyoon Yoon

Wol-Young Kim

The present disclosure relates to a manufacturing method for 4-methoxypyrrole derivatives. The embodiment of the present disclosure is useful for industrial mass production of 4-methoxypyrrole derivatives, because the process efficiency and yield are improved, and the use of hazardous reagents and environmental polluting reagents is avoided.

Manufacturing method for 4-methoxypyrrole derivatives

The present invention relates to a method for preparing intermediates of 4-methoxypyrrole derivatives. The preparation method according to the present invention has advantages that the production cost can be lowered by using inexpensive starting materials, a high-temperature reaction is not required as a whole, inexpensive and non-explosive reagents are used instead of (trimethylsilyl)diazomethane, and further an intermediate of 4-methoxypyrrole derivatives can be prepared as a whole at a high yield.

Method for preparing intermediate of 4-methoxypyrrole derivative

The present invention relates to a method for preparing intermediates of 4-methoxypyrrole derivatives. The preparation method according to the present invention has advantages that a high-temperature reaction is not required as a whole, inexpensive and non-explosive reagents are used instead of (trimethylsilyl)diazomethane, and further an intermediate of 4-methoxy pyrrole derivatives can be prepared as a whole at a high yield.

The present invention provides a process for preparing an ertapenem-containing lyophilized formulation, comprising the use of hydroxypropyl &#x3b2;-cyclodextrin as both a cryoprotective agent and a stabilizing agent.

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Gyeonggi-do, South Korea

Jeong-Taek Shin