Alteogen, Inc.

Jeong Soo Cho

Soon Jae Park

Minsoo Byun

Ji-Sun Kim

Sang Hoon Yun

Hye Shin Chung

Hyung-Nam Song

Ki Seok Nam

Kibum Park

Sun Ah You

Kyuwan Kim

Disclosed is a method for producing hyaluronidase or a variant thereof. Specifically, the method is capable of changing the N-glycan levels under culture conditions including a controlled concentration of glucose in the culture medium and a decreased culture temperature for a specific culture time period, thereby increasing the specific activity by 10% or more and improving the quality and production yield.

Method for producing recombinant hyaluronidase

The present invention relates to a method for preparing a fusion protein having an IgG Fc domain and, specifically, to a method for preparing a fusion protein having an IgG Fc domain, the method additionally comprising a step of culturing cells, which produce the fusion protein, at a decreased culture temperature, thereby increasing cell growth and cell viability so as to increase fusion protein productivity and inhibiting aggregate generation so as to improve quality and production yield.

Method for producing fusion protein having IgG Fc domain

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Daejeon, South Korea

Jeong Soo Cho