Samjin Pharmaceutical Co., Ltd.

Samjin Pharm. Co., Ltd.

Jeong-Ho Joo

Eui-Hwan Cho

Sun-Gan Chung

Ho-Seok Kwon

Sun-Hwan Lee

Dong-Wook Kang

Jae-Eung Lee

Young-Hee Lee

Jae-woong Lee

Byung-Chul Kim

Hyun-Tae Kim

Hyun-Nam Myung

Joong-Young Kim

Jae-Woong Lee

A pyrimidinedione derivative of formula (I) or a pharmaceutically acceptable salt thereof exhibits excellent inhibitory activity against hepatitis C virus.

Use of pyrimidinedione derivative for preventing or treating hepatitis C

The present invention relates to pyrimidinedione derivatives of following formula (I) which are useful as antiviral agents, especially as agents for treatment of AIDS, pharmaceutically acceptable salts thereof, process for the preparation thereof and pharmaceutical compositions containing the same, wherein R represents cyclopropyl; cyclobutyl; cyclohexyl; unsubstituted or mono-, di- or trisubstituted phenyl with a group selected from hydroxy, C&#x2013;Calkyl, C&#x2013;Calkoxy, halogen, trifluoromethyl, cyano and amino; 1- or 2-naphthyl; 9-anthracenyl; 2-anthraquinonyl; unsubstituted or substituted pyridyl with a group selected from C&#x2013;Calkyl, C&#x2013;Calkoxy, cyano and halogen; 2-, 3- or 4-quinolinyl; oxiranyl; 1-benzotriazolyl; 2-benzoxazolyl; furanyl substituted with C&#x2013;Calkoxycarbonyl; C&#x2013;Calkylcarbonyl; or benzoyl, Rrepresents halogen or C&#x2013;Calkyl, Rand Rrepresent independently hydrogen or C&#x2013;Calkyl, X represents oxygen atom, and Y represents oxygen atom, sulfur atom or carbonyl.

Antiviral pyrimidinedione derivatives and process for the preparation thereof

Piperazine derivatives and process for the preparation thereof

The present invention relates to new 9-aminoacridine derivatives of general formula (I), wherein A is hydrogen or (II) (wherein X is oxygen or sulfur, R , R , R , R and R are independently hydrogen, halogen, nitro, amino, hydroxy, C -C lower alkylhydroxy, C -C lower alkylamino, C -C alkyl, C -C lower alkoxy or C -C lower alkyloxycarbonyl and m and n are independently an integer of 0, 1 or 2), R , R , R and R are independently C -C alkyl or C -C lower alkoxy, and Y is hydrogen, amino, &mdash;N&boxH;CHR&prime;(wherein R&prime; is hydrogen, benzyl, C -C alkyl or C -C lower alkylamino), (III) (wherein R&Prime; is hydrogen, benzyl, C -C alkyl or C -C lower alkylamino, and R&prime;&Prime; is hydrogen, benzyl, C -C alkyl or amino protecting group) or (IV) (wherein, X is as defined above, R &prime;, R &prime;, R &prime;, R &prime; and R &prime; are independently hydrogen, halogen, nitro, amino, hydroxy, C -C lower alkylhydroxy, C -C lower alkylamino, C -C alkyl, C -C lower alkoxy or C -C lower alkylcarboxy, and q and r are independently an integer of 0, 1 or 2) or its pharmaceutically acceptable salt, and process for the preparation thereof.

9-aminoacridine derivatives and process for the preparation thereof

Antiviral substituted pyrimidinedione homocarbocyclic nucleoside

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Anyang-si, South Korea

Jeong-Ho Joo