Seoul National University

Autotac Inc.

Jeong Eun Na

Yong Tae Kwon

Chang Hoon Ji

Hyun Tae Kim

Su Jin Kim

Ji Eun Lee

Ki Woon Sung

Min Ju Lee

Su Ran Mun

Chang Min Park

Srinivasrao Ganipisetti

Chan Hoon Jung

Eui Jung Jung

Hee Yeon Kim

Chang An Jung

Eun Hye Jeong

Yu Jin Seo

Ah Jung Heo

Ha Rim Choi

One aspect of the disclosure relates to a cargo delivery system comprising an autophagy targeting ligand and a target-binding ligand. In one aspect of the disclosure, by comprising an autophagy targeting ligand, cargo, which is a target-binding ligand that specifically binds to a target, is delivered to the p62 protein and autophagy is activated, so that depending on the type of target-binding ligand used, a target to be degraded can be selectively and directly removed. Accordingly, the cargo delivery system according to an aspect of the disclosure may be used in pharmaceutical compositions or food compositions for preventing, alimerating, and treating various diseases.

Cargo delivery system and composition comprising the same

The present specification discloses a novel benzyloxy pyridine derivative compound represented by Chemical Formula 1, a salt thereof, a stereoisomer thereof, a hydrate thereof, or a solvate thereof, and novel uses thereof. The uses comprise the uses in the preparation of a composition for activating autophagy, a composition for activating p62 protein, a composition for inducing oligomerization of p62 protein, or a composition for ameliorating, preventing or treating a disease caused by misfolded protein.

Benzyloxy pyridine derivatives and uses thereof

Growing community of inventors

Seoul, South Korea

Jeong Eun Na