Novartis Ag

Mb-holding Gmbh & Co. Kg

Technische Universitat Darmstadt

N-zyme Biotec Gmbh

Dohler Gmbh

Jens Zotzel

Achim Müller

Ralf Pasternack

Monika Knuth

Christine Reiff

Achim Mueller

Katharina Schmid

Katharina Nikolaus

Stefan Marx

Hans-Lothar Fuchsbauer

Kai Oertel

Christine Reiff, Geb Schmitt

Alla Sarafeddinov

Heinz-Peter Germann

Joachim Tretzel

Heribert Warzecha

Jascha Volk

Process for the tanning of hides and skins, characterized in that hides and skins are treated with tanning agents containing deglycosylated iridoids and/or deglycosylated secoiridoids, excluding tanning agents containing genipin.

Agent and method for tanning skins and pelts

The invention relates to a process for producing biomedical articles, in particular, silicone hydrogel contact lenses having durable hydrophilic chitosan coating. The chitosan coating is covalently attached to the medical device by performing a crosslinking reaction between chitosan and the carboxylic groups on the surface of a medical device directly in a sealed package during autoclave. The coated biomedical articles obtainable by the process of the invention have desirable characteristics regarding adherence to the substrate, durability, hydrophilicity, wettability, biocompatibility and permeability and are thus especially useful in the field of ophthalmic devices.

Method for coating silicone hydrogels

The invention relates to a process for the manufacture of a composite materials comprising the steps of (a) providing a hydrophobic organic bulk material, and (b) applying a hydrophilic surface coating on the hydrophobic organic bulk material by first non-covalently attaching to the surface of the bulk material a water-soluble peptide comprising a hydrophobic moiety; and then chemically or enzymatically crosslinking the water-soluble peptide. The composite materials manufactured according to the process of the invention have desirable characteristics regarding adherence to the substrate, durability, hydrophilicity, wettability, biocompatibility and permeability and are thus particularly useful as ophthalmic devices.

Process for the manufacture of a composite material

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Darmstadt, Germany

Jens Zotzel