Basf Se Corporation

Symrise Ag

Jens Wittenberg

Wolfgang Siegel

Thomas Subkowski

Claus Bollschweiler

Ralf Pelzer

Michael Backes

Arnold Machinek

Hubert Loges

Horst Surburg

Heiko Oertling

Ulrike Simchen

Stephan Freyer

Michael Krohn

Gabriele Iffland

Suman Thotla

Holger Zinke

Stefanie Demming

Yvonne Hoelzl

Florian Garlichs

Till Christian Brueggemann

Rahim Brodhage

Silke Weyland

Jekaterina Ongouta

Martin Weisel

Benoît Join

Christian Brueggemann

Susanne Mundt

Tom Somers

Till Christian BRÜGGEMANN

The present invention relates to 2,4-diethylocta-2,6-dienal and a method of preparing same, to the use of 2,4-diethylocta-2,6-dienal as aroma chemical; to the use of 2,4-diethylocta-2,6-dienal for preparing an aroma chemical composition or for modifying the aroma character of an aroma chemical composition; to an aroma chemical composition containing 2,4-diethylocta-2,6-dienal; and to a method of preparing an aromatized composition or for modifying the aroma character of an aromatized composition.

2,4-diethylocta-2,6-dienal and its use as aroma chemical

The invention relates primarily to a method of modulation, preferably of in vitro and/or in vivo modulation, of the cold menthol receptor TRPM8, wherein the receptor is contacted with at least one modulator selected from the group consisting of the compounds of the structure type 1 described herein. The present invention further relates to corresponding uses and compositions comprising such compounds.

Use of physiological cooling active ingredients, and compositions comprising such active ingredients

The invention relates to new types of modulators of the cold menthol receptor TRPM8, to methods of modulating the TRPM8 receptor using these modulators; and in particular the use of the modulators for inducing a sensation of coldness; and also the articles and compositions produced using these modulators.

Low molecular weight modulators of the cold menthol receptor TRPM8 and use thereof

The invention relates to a TRPM8 modulator for achieving a cooling effect on the skin or a mucous membrane.

Use of physiological cooling active ingredients, and agents containing such active ingredients

The invention relates to a process for continuously preparing di-C-alkyl succinates by reacting succinic acid with an C-alkanol in the presence of a fixed-bed heterogeneous acidic esterification catalyst in a tubular reactor at a temperature in the range of from 60 to 100&#xb0; C., wherein a mixture, comprising succinic acid, C-alkanol, mono-C-alkyl succinate, di-C-alkyl succinate and water, is formed in a mixing stage and fed to the entrance of the tubular reactor, and wherein 5 to 75% of the outlet flow rate of the tubular reactor are recycled directly to the mixing stage as a recycle stream, and the molar ratio of C-alkanol to succinic acid added to the mixing zone, and not including the C-alkanol and succinic acid at the recycle stream, being in the range of from 2.0 to 9.5. The invention furthermore relates to a process for separating the reactor effluent of an esterification of succinic acid with an C-alkanol to give di-C1-3-alkyl succinates by distillation, wherein the separation is performed in a divided wall column in which C-alkanol and water are removed in a top draw of the column, di-C-alkyl succinate is removed in a side draw of the column, and wherein mono-C-alkyl succinate and succinic acid are removed in a bottom draw of the column.

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The invention relates to a process for continuously preparing di-C-alkyl succinates by reacting succinic acid with an C-alkanol in the presence of a fixed-bed heterogeneous acidic esterification catalyst in a tubular reactor at a temperature in the range of from 60 to 100&#xb0; C., wherein a mixture, comprising succinic acid, C-alkanol, mono-C-alkyl succinate, di-C-alkyl succinate and water, is formed in a mixing stage and fed to the entrance of the tubular reactor, and wherein 5 to 75% of the outlet flow rate of the tubular reactor are recycled directly to the mixing stage as a recycle stream, and the molar ratio of C-alkanol to succinic acid added to the mixing zone, and not including the C-alkanol and succinic acid at the recycle stream, being in the range of from 2.0 to 9.5. The invention furthermore relates to a process for separating the reactor effluent of an esterification of succinic acid with an C-alkanol to give di-C-alkyl succinates by distillation, wherein the separation is performed in a divided wall column in which C-alkanol and water are removed in a top draw of the column, di-C-alkyl succinate is removed in a side draw of the column, and wherein mono-C-alkyl succinate and succinic acid are removed in a bottom draw of the column.

The invention relates to novel modulators of the cold menthol receptor TRPM8, to a method for modulating the TRPM8 receptor using said modulators; to the use of the modulators for induction of cold sensation; and to objects and means produced using said modulators.

Detection and use of low molecular-weight modulators of the cold-menthol receptor TRPM8

Growing community of inventors

Limburgerhof, Germany

Jens Wittenberg