Jpt Peptide Technologies Gmbh

Institut Fue Diagnostikforschung Gmbh

Jens Schneider-Mergener

Frank Osterkamp

Jurgen Conrad

Gerd Hummel

Ulf Reimer

Ludger Dinkelborg

Dirk Scharn

Wolfgang Kramp

Hans Martin Schier

Laurence Jobron

Renate Steinbrecher

Wolfgang Hohne

Reinhard Malin

Soren Panse

Cornelius Frommel

Mike Schutkowski

Sebastian Erber

Liying Dong

Gabriele Kuttner

The invention relates to a method for determining the substrate specificity of an enzymatic activity comprising the following steps: providing an assembly comprising a plurality of amino acid sequences on a planar surface of a support material, whereby the amino acids are directionally immobilized; contacting and/or incubating of an enzymatic activity with the assembly; and detection of a reaction between one of the amino acid sequences that are immobilized on the assembly and the enzymatic activity. According to the invention, during the reaction of the enzymatic activity with the assembly, a change in the molecular weight of at least one of the amino acid sequences takes place.

Method for determining the substrate specificity of an enzyme

These invention relates to metal-complexing, cysteine-free peptides which may be coupled to an organ-specific probe directly or via a linker and are thus enriched as conjugates specifically in tumors, organs, tissues or centers of inflammation. The organ-specific probes used are, for example, antibodies or part-sequences of antibodies against tumor-associated antigens, e.g. the carcino-embryonal antigen (CEA, which are thus specifically enriched in tumors. The invention also relates to processes for producing the metal-complexing cysteine-free peptides and their conjugates. The present invention also relates to the use of the conjugates as components of a kit for in vivo diagnosis or in vivo therapy and radio-pharmaceuticals containing these conjugates together with radio-isotopes. The organ-specific conjugates are used to image tumors, organs or centers of inflammation.

Metal-binding cystein-free peptides for diagnostic and therapeutical purposes, methods for their production, and pharmaceuticals containing these compounds

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Berlin, Germany

Jens Schneider-Mergener