Hewlett-packard Company

Koninklijke Philips Corporation N.V.

Other

Agilent Technologies, Inc.

Biocartis, Nv

Jens-Peter Seher

David A King

Gerhard Pross

Christopher Sprague Boit

Markus Maile

Ronald Cornelis De Gier

Richard J Pittaro

Adrianus Wilhelmus Dionisius Maria Van Den Bijgaart

Michiel Johannes Jongerius

Michiel De Jong

Andreas Boos

Erwin Flachslaender

Michael Frankenreiter

Martin Wunderling

Chris Van Haag

Johannes Bacher

Rainer Rometsch

Danny Genius Aldegonda Schaefer

Gerd Luedke

Cartridge and method for the detection of the presence, absence and/or amount of a target nucleotide sequence in a sample comprising one or more nucleic acid sequences. The cartridge comprises a one or more nucleic acid sequences, and the cartridge includes a generic part and one or more separate application-specific parts, which are connectable to the generic part.

Cartridge, system and method for automated medical diagnostics

A closure device () for a container () includes a filling device () that can be attached to an opening () of the container () A closure structure such as a membrane (), a system (), or a duckbill closure () is attached to the filling device () in such a way that the opening () of the container () is sealed when the filling device () is attached to the opening (). The closure structure is coated at least partially with polytetrafluoroethylene () on one side () that is accessible from outside the container () in the assembled state of the filling device () on the container ().

Closure device for a container

A system () for point of care diagnosis and/or analysis of a body fluid of a patient, includes at least one cartridge (), at least one handheld diagnosis and/or analysis device () and at least one data processing device (). Each cartridge () comprises a sample receiving room () for receiving a sample of the body fluid to be diagnosed and/or analyzed, a diagnosing and/or analyzing arrangement () for measuring at least one physiological parameter of the sample, and a first interface () for connecting the cartridge () to the handheld device (). Each handheld device () comprises one second interface () for connecting one of said cartridges () to the handheld device (), a measurement arrangement () co-operating with the connected cartridge () for measuring the parameter and generating measurement data thereof, and one third interface () for connecting the handheld device () to the data processing device (). Each data processing device () comprises one fourth interface () for connecting one of said handheld devices () to the data processing device (), and a data processing unit () co-operating with the connected handheld device () for further processing the measurement data.

System for point of care diagnosis and/or analysis

The present invention relates to an aptitude test system () which includes at least one object () which is provided with a data carrier () on which data associated with the object () is stored, as well as a test device () which includes a reading apparatus () whereby the data of the data carrier () can be transfer-red to a computer (). The data includes aptitude data which characterizes at least one permissible application for the associated object (). The computer () has access to current application data which characterizes a concrete application intended for the relevant object (). For aptitude testing of the relevant object () the computer evaluates the aptitude data thereof and the actual application data. The computer () outputs a release signal when the object () is suitable for the intended application.

Systems for aptitude tests for testing an object for its intended application

A fluid movement system for moving a sample fluid is preferably included in a cartridge to be inserted into a reading device. The fluid movement system includes a pressure variation means for moving the sample fluid under the influence of a pressure variation applied to the fluid movement system, and a timing means for controlling the timing for releasing a pressure in the pressure variation means.

Pressure-variation fluid transport, in particular for body-fluid analysis

Optical vehicle display having a set of LEDs arranged in a matrix and having a control circuit which acts as a controllable current source and as controllable voltage source, so that a constant current can be applied for each LED and the respective voltage is established accordingly. An optical vehicle display designed in this way permits a design as a taillight, brake light, flashing indicator and the like in a motor vehicle with favorable production at the same time due to reduced faulty assembly and simple adjustment of the light values.

Optical vehicle display

An optical display device has a set of LEDs arranged in a matrix and includes control circuitry which acts as a controllable current source and as controllable voltage sources. The control circuitry enables a constant current to be applied for each LED, and respective voltages to be established accordingly. Due to the additional logic circuitry which deliver different clock pulses at different frequencies for cyclic switching of at least one LED, signals that are visible to the human eye are generated and at the same time signals that are not visible to the human eye are also generated. The signals that are not visible are digitally coded and transmitted for appropriately adapted reading devices. Thus additional information for a variety of purposes can be made available, especially in the communications and traffic area, simultaneously with the lighting up of the LEDs. This refers in particular to traffic control systems, diagnosis and monitoring. An optical display device designed in this way permits a design, for example, as a taillight, brake light, flashing indicator light and the like in a motor vehicle or with other traffic and communications means and also in equipment in production facilities while permitting favorable production at the same time due to reduced fault in assembly and ease of adjustment of the light values.

Optical display device and method of operating an optical display device

A laser system includes a gain medium for providing and amplifying a laser beam within an optical resonator. According to the invention, the laser system actively provides a plurality of different optical modes for stabilizing the laser beam, preferably by forcing the laser beam to jump between different optical modes more frequent than environmental disturbances occur. Providing the plurality of different optical modes can be achieved e.g. by varying the phase of the laser beam and/or by varying the optical length of the optical resonator. The laser system can be employed in a gas monitoring system, e.g. for monitoring a respiration and/or anaesthetic gas, for providing a Raman spectrum of the gas to be monitored.

Laser system tolerating disturbances using multiple modes

An apparatus for detecting a target substance in a pixel array is provided. The apparatus has a light source to emit a light suitable for exciting the target substance in the array, a total internal reflection (TIR) member, and a light detector. The TIR member has a TIR surface on which the array is located. The light from the light source passes into the TIR member and is reflected by the TIR surface. The array is within an evanescent field region at the TIR surface. The light detector is adapted to detect light emitted from the array as a result of evanescent excitation of the target substance.

Evanescent scanning of biochemical array

The presence of trace materials in a sample is detected using both macroscopic and microscopic properties. A detector includes a light source and an optical resonator. The light source may be located either inside the resonance cavity of the resonator or outside the cavity, in which case it may be a semi-conductor such as a semi-conductor laser or a superluminescent diode. The detector also includes at least one reflective member that has a total internal reflection (TIR) surface and may be a passive device or an active gain element. Light from the light source is preferably focussed onto a single point of reflection on the TIR surface. The test sample is positioned within the evanescent field region of the TIR surface. Optical changes arising within the evanescent field region, such as excitation of fluorescence in the sample, changes in its refractive index, and changes in the resonant frequency of the optical resonator, are then detected. These changes are then sensed to determine the amount or at least presence of analyte located at the TIR surface.

Apparatus and method for intracavity sensing of microscopic properties

Method for intracavity sensing of macroscopic properties of chemicals

The presence of trace materials in a sample is detected using both macroscopic and microscopic properties. A detector includes a light source and an optical resonator. The light source may be located either inside the resonance cavity of the resonator or outside the cavity, in which case it may be a semi-conductor such as a semi-conductor laser or a superluminescent diode. The detector also includes at least one reflective member that has a total internal reflection (TIR) surface and may be a passive device or an active gain element. Light from the light source is preferably focussed onto a single point of reflection on the TIR surface. The test sample is positioned within the evanescent field region of the TIR surface. Optical changes arising within the evanescent field region, such as excitation of fluorescence in the sample, changes in its refractive index and changes in the resonant frequency of the optical resonator, are then detected. These changes are then sensed to determine the amount or at least presence of analyte located at the TIR surface.

Apparatus for intracavity sensing of macroscopic properties of chemicals

A measuring instrument utilizing surface plasmon resonance is described. The instrument employs no moving mechanical part because it produces the resonance by changing the parameters either electrically or acoustically, and it detects the reflection by a stationary detector.

Surface plasmon resonance measuring instruments

A method and apparatus for detecting the presence and/or concentration of biomolecules, in particular DNA, by providing a boundary surface between an optically denser medium and an optically rarer medium. Biomolecules adsorb to the boundary surface and alter the characteristics of impinging light. The method and apparatus use surface plasmon resonance (SPR) to excite the biomolecules. The angle of incidence of the impinging light is maintained at the angle at which SPR occurs, thereby controlling the energy transferred to the biomolecules. The energy transferred to the biomolecules causes the biomolecules to generate excitation light which is reflected and monitored at the boundary surface. The angle of incidence is controlled by rotating a desk such that the intensity of the reflected light is always maintained at a minimum which ensures that the angle of incidence is equal to the angle at which SPR occurs.

Method and apparatus for detecting the presence and/or concentration of

A pneumatic connector for an automated non-invasive blood pressure monitor having a connector body (1) containing two oppositely arranged hollow cavities (8) for insertion of a differential pressure sensor in each cavity. The hollow cavities are connected by a bore (10) which is in connection with the main airway (6,7) in the connector body (1). Additionally, both differential pressure sensors have differential pressure sensors which are connected to the ambient air via a secondary airway.

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Stuttgart, Germany

Jens-Peter Seher