Meditest Institut Fur Medizinisch Pharmazeutische Untersuchungen Gmbh

Chemisches Laboratorium Fritz-walter Lange Gmbh & Co Kg

Jens Muller

Fritz-Walter Lange

Haireddin Jacobi

Gert Haffner

The present invention pertains to novel (2-oxo-pyrrolidine-1)-acetic hydrazides, methods for preparation and subsequent treatment therewith, and pharmaceutical preparations containing the same.

(2-Oxo-pyrrolidines)-acetic hydrazides

The process provided for the production of high-purity 1,3-bis-(.beta.-ethexyl)-5-amino-5-methyl-hexahydropyrimidine, also known as hexetidin, by reacting 1,3-bis-(.beta.-ethylhexyl)-5-nitro-5-methyl-hexahydropyrimidine with naphthalene-1,5-disulphonic acid in a solvent to selectively precipitate the novel intermediate compound 1,3-bis-(.beta.-ethylhexyl)-5-nitro-5-methyl-hexahydropyrimidine-naphthale ne-1,5-disulphonate, which is separated off, treated with aqueous alkali to produce 1,3-bis-(.beta.-ethylhexyl)-5-nitro-5-methyl-hexahydropyrimidine, and subsequently hydrogenated to produce high-purity hexetidin.

1,3-Bis-(.beta.-ethylhexyl)-5-nitro-5-methyl-hexahydropyrimidine-na

The process provided for the production of high-purity 1,3-bis-(.beta.-ethexyl)-5-amino-5-methyl-hexahydropyrimidine, also known as hexetidin, by reacting 1,3-bis-(.beta.-ethylhexyl)-5-nitro-5-methyl-hexahydropyrimidine with naphthalene-1,5-disulphonic acid in a solvent to selectively preciptitate the novel intermediate compound 1,3-bis-(.beta.-ethylhexyl)-5-nitro-5-methyl-hexahydropyrimidine-naphthale ne-1,5-disulphonate, which is separated off, treated with aqueous alkali to produce 1,3-bis-(.beta.-ethylhexyl)-5-nitro-5-methyl-hexahydropyrimidine, and subsequently hydrogenated to produce high-purity hexetidin.

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Gauting, Germany

Jens Muller