Other

Zeneca Limited

Gist-Brocades N.v.

Jens-Michael Schroder

Enno Christophers

Oliver Wiedow

Michael Derek Edge

David Pioli

Polypeptides, in particular the polypeptide of formula I: and analogues thereof which possess inhibitory activity against human leukocyte elastase. The polypeptides may be obtained by expression using plasmidic expression systems in hosts such asand yeast, the polypeptide of formula I being also obtainable from psoriatic plaques.

Nucleic acids

polypeptides and polypeptide analogues

Polypeptides, in particular the polypeptide of formula I: ##STR1## and analogues thereof which possess inhibitory activity against human leukocyte elastase. The polypeptides may be obtained by expression using plasmidic expression systems in hosts such as E. Coli and yeast, the polypeptide of formula I being also obtainable from psoriatic plaques.

Polypeptides and polypeptide analogues

A substance is prepared having interleukin-8 inhibiting activity by extracting psoriatic scales and separating the extract on several successive HPLC columns, using an assay for IL-8i activity based on the inhibition of myeloperoxidase release and/or of the neutrophil chemotaxis of a reference sample. The substance is suitable for the preparation of anti-inflammatory medicines.

Substance with interleukin-8 inhibiting activity and process for its

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Blumenthal, Germany

Jens-Michael Schroder