Sartorius Stedim Biotech Gmbh

Jens Ludwig

Oscar-Werner Reif

Gerhard Greller

Isabelle Gay

Michael Bates

Wolfgang Kahlert

Stefan Weisshaar

Stephane Baud

Guenther Pradel

Magail Barbaroux

Sebastian Chaussin

Juergen Van Den Boogaard

Sebastien Chaussin

Magali Barbaroux

Gerid Hellwig

Stefan Zeuch

Markus Haeusser

Günter Pradel

Juergen Van Den Boogard

Stephanie Baud

Sébastien Chaussin

Markus HÄUSSER

Jürgen Van Den Boogaard

Gunther Pradel

Magail Barbarous

Günther Pradel

A mixing apparatus () for mixing a fluid and/or solid. The mixing apparatus includes a mixing container () having an interior in which the fluid and/or solid can be arranged. A feed-through passage () extends through a container wall () of the mixing container. A drive shaft () is fed through the feed-through passage, to drive a stirring element () arranged at least partly in the interior of the mixing container. The stirring element is used to mix the fluid and/or solid arranged in the mixing container. A drive-side shaft end () of the drive shaft couples the drive shaft to a drive () arranged outside of the mixing container. An adjustable seal () seals off the feed-through passage. A setting apparatus () is provided to switch the adjustable seal into at least two sealing operation states having different sealing effects.

Mixing apparatus and method for operating a mixing apparatus

A bioreactor () having a container (), a shaft housing () for guiding a shaft () through a wall (), a stirrer () connected to the shaft () in the interior () of the container (), and a drive () arranged outside the container () and connectable to the shaft (). The shaft () is mounted in the shaft housing () via at least one ball bearing () and is sealed in relation to the shaft housing () by at least one seal (). The seal () is configured as a radial shaft seal () having two sealing lips () that are arranged one behind the other in the longitudinal direction of the shaft () and are able to run on the shaft () without lubricant.

Bioreactor

A mixing vessel includes a flexible container, elements for mixing its contents, aeration elements, a drain/lower bearing port having a rigid flange provided with a drain passage, attached in a tight manner to the lower portion of the container wall, supporting a lower bearing that is adjacent to the drain passage. The vessel includes an extended element for dispensing aeration gas and is spaced essentially radially from the drain/bearing port; at least one tubular element for dispensing aeration gas extends from the extended dispensing element, in the inside space, along the inside surface of the lower portion and the side portion of the wall of the container and extends on the outside of the container from the upper portion; at least one mixing element is spaced essentially from the lower portion of the container wall, from the lower bearing, and from at least one extended element for dispensing aeration gas.

Mixing vessel

A disposable mixing vessel comprising a flexible container, a centrally disposed shaft having first and second ends with one or more impellers thereon and a magnetic element associated with a first shaft end, a first flange adapted to rotatably engage the first shaft end and a second flange adapted to rotatably engage the second shaft end.

Disposable mixing vessel

A method of mixing including providing a flexible container which comprises at least two components, assembling the components from outside the flexible container to form a centrally disposed magnetic driven shaft with at least one impeller, whereby the integrity of the flexible container is maintained, filling the flexible container having the centrally disposed magnetic driven shaft with one or more ingredients of the contents to be mixed; engaging a magnetic element of the centrally disposed magnetic driven shaft with an external magnetic drive element; analyzing the contents of the flexible container using at least one sensor or a sampling line on the flexible container; and draining the contents of the flexible container through a drain port at the bottom of the flexible container.

Method of mixing

The invention relates to a waste gas system for bioreactors having a hydrophobic sterile filter, arranged at the end, and a heat exchanger which protects the sterile filter against blocking by liquid media. The gas outflow duct for discharging waste gas from a bioreactor vessel is divided in a cooling zone of the heat exchanger into a multiplicity of subducts and is extended in a heating zone of the heat exchanger to a calming zone. Due to the multiplicity of subducts, a considerably larger surface area for the removal of heat from the waste gas is available, with the result that in the case of laminar flow of the waste gas through the subducts a high effectiveness of the separation of liquids from the waste gas can be achieved. In the heating zone, the waste gas can heat up again due to the reduced flow rate until it reaches the hydrophobic sterile filter by way of taking up heat from the surroundings to a such a degree that the relative vapor contents are below 100% and separation of liquids from residual vapors at or in the hydrophobic sterile filter is precluded.

Waste gas system for bioreactors

Growing community of inventors

Juehnde, Germany

Jens Ludwig