New York University

Columbia University

Medical University of South Carolina

Musc Foundation for Research Development

Jens Jensen

Joseph Helpern

Manlio G Abele

Henry Rusinek

Els Fieremans

Ali Tabesh

Ramesh Chandra

Glyn Johnson

Dmitry Novikov

Gary M Brittenham

Daniel Kim

Sai Kam Hui

Exemplary method, system, and computer-accessible medium can be provided for determining a measure of diffusional kurtosis by receiving data relating to at least one diffusion weighted image, and determining a measure of a diffusional kurtosis as a function of the received data using a closed form solution procedure. In accordance with certain exemplary embodiments of the present disclosure, provided herein are computer-accessible medium, systems and methods for, e.g., imaging in an MRI system, and, more particularly for facilitating estimation of tensors and tensor-derived measures in diffusional kurtosis imaging (DKI). For example, DKI can facilitate a characterization of non-Gaussian diffusion of water molecules in biological tissues. The diffusion and kurtosis tensors parameterizing the DKI model can typically be estimated via unconstrained least squares (LS) methods. In the presence of noise, motion, and imaging artifacts, these methods can be prone to producing physically and/or biologically implausible tensor estimates. The exemplary embodiments of the present disclosure can address at least this deficiency by formulating an exemplary estimation problem, e.g., as linearly constrained linear LS, where the constraints can ensure acceptable tensor estimates.

System, method and computer accessible medium for providing real-time diffusional kurtosis imaging and for facilitating estimation of tensors and tensor-derived measures in diffusional kurtosis imaging

One aspect of the present disclosure relates to a system that can perform double pulsed diffusional kurtosis imaging (DP-DKI). Image data can be received. The image data can be acquired using a double pulsed field gradient (d-PFG) diffusion sequence. A six dimensional (6D) diffusional kurtosis for the image data can be determined. A magnitude of the image data can be determined in terms of the 6D diffusional kurtosis. DP-DKI can isolate the contributions to the d-PFG diffusion sequence, which can represent leading diffusion effects, that cannot be seen from single pulsed field gradient (s-PFG) diffusion sequences.

Systems and methods for double pulsed diffusional kurtosis imaging

One aspect of the present disclosure relates to a system that can determine a kurtosis diffusion orientation distribution function (dODF) that can, for example, be used with diffusional kurtosis imaging fiber tractography (DKI-FT). The system can include a non-transitory memory storing computer-executable instructions and a processor that executes the computer-executable instructions to perform the following operations. Diffusion magnetic resonance imaging (dMRI) data can be received. Based on the dMRI data, a diffusion tensor (DT) and a diffusional kurtosis tensor (DKT) can be determined. A kurtosis dODF can be determined for the dMRI data based on the DT and the DKT. The kurtosis dODF extends a Gaussian approximation of the DT to include non-Gaussian corrections of the DKT.

Systems and methods for determining white matter fiber tractography

Exemplary embodiments of a methodology, procedure, system, method and computer-accessible medium can be provided to obtain particular information relating to at least one transport property of a material containing at least one membrane, and to determine, e.g., a permeability of the membrane of the material and/or a surface area of the membrane of the material, as a function of, e.g., the obtained particular information.

System, method and computer-accessible medium for determining membrane properties relating to diffusion

Exemplary embodiments of system, method and computer-accessible medium can be provided in accordance with the present disclosure can be provided for generating a plurality of images associated with at least one anatomical structure using magnetic resonance imaging (MRI) data. For example, using such exemplary embodiments, it is possible to obtain at least one multi-echo fast spin-echo (FSE) pulse sequence based on the MRI data, which can include, e.g., hardware specifications of the MRI system. Further, it is possible to generate each of the images based on a particular arrangement of multiple echoes produced by the multi-echo FSE pulse sequence(s).

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Methods, systems, software arrangements and storage medium for measuring the magnetic field correlation function ('MFC'), and more particularly, to methods for measuring the magnetic field correlation function utilizing asymmetric spin echoes. Asymmetric Dual Spin Echo Sequences ('ADSE') and Echo Planar Imaging Asymmetric Dual Spin Echo Sequences (&#x201c;EPI-ADSE&#x201d;) may be employed to apply multiple echoes to a sample and acquire data from which the MFC may be determined.

Method, system and software arrangement for measuring magnetic field correlation

Method, system and software arrangement, for measuring magnetic field correlation

A computer-implemented method for optimizing the design of an electromagnetic coil arrangement that generates a uniform magnetic field in a desired region, with the electromagnetic coil arrangement having a number of coils and a shape defined by r and z, where r is the radial coordinate of a cylindrical coordinate system having (r, z, &#x3c6;) coordinates, and z is the axial coordinate of the cylindrical coordinate system. The method has an important use for designing superconductive or resistive coil arrangements for MRI systems. The core of the method is to compute a solution to a master equation (25) for a set of parameters lambda_j which define the coil arrangement and the currents needed. An important advantage is that the resultant coil arrangement has a minimum volume, which saves on material, or uses a minimum power.

Methods for optimizing magnetic resonance imaging systems

A magnetic structure generating a uniform magnetic field within a region of interest using permanently magnetized prism-shaped blocks of magnetic material positioned around a cavity and which constitute the predominant generator of the uniform magnetic field in the desired region of interest. The magnetic structure has a plane surface comprising a high permeability ferromagnetic member interfacing with a first side of the cavity and forming a single pole piece of the magnetic structure. The magnetic structure produces within the cavity adjacent the single pole piece the uniform magnetic field and collects the magnetic flux flowing through the single pole piece and through the cavity, with the region of interest being located adjacent the single pole piece. A second side of the cavity generally opposite to the first side is open to a surrounding medium and forms an interface with the surrounding medium but not with a magnetic member. The magnetic structure is designed assuming a hypothetical high permeability membrane parallel to the single pole piece and located where the open second side of the cavity will be made, the high permeability membrane forming an equipotential surface at the interface with the surrounding medium. This minimizes the fringe field generated in the surrounding medium when the second side of the cavity is opened.

Open unipolar magnetic structure

A magnetic structure generating a substantially uniform magnetic field within a region of interest using permanently magnetized wedge-shaped blocks of magnetic material. In a preferred embodiment, the permanently magnetized wedge-shaped blocks are provided in pairs positioned on opposite sides of the x z plane of an arbitrary x,y,z coordinate system, and each of the blocks are magnetized in certain directions. The uniform field is created in the vicinity of the z axis. In another embodiment, the parts of the structure below the x-axis are replaced by a high-permeability, soft magnetic plate to form a so-called mirror system. In still another embodiment, permanently magnetized blocks positioned outside of the wedge-shaped blocks are employed as the main compensation means for field distortions arising from the practical need to truncate the wedge-shaped blocks to a practical size. An important application for the magnetic structure of the invention is MRI, as it can be configured as an open structure accessible to medical intervention during the MRI.

Generation of highly uniform magnetic fields with magnetized wedges

Strapped open magnetic structure, particularly useful in nuclear magnetic resonance imaging applications, which provides a substantially uniform magnetic field within a region of interest while allowing access by a surgeon to a patient via an opening at the top of the magnetic structure. The magnetic structure comprises nested inner and outer magnetic structures separated by ferromagnetic material or pole pieces and surrounded by a ferromagnetic yoke. The structure contains one or more thin layers or straps of high magnetic permeability material aligned substantially along equipotential surface(s) of an associated closed magnetic structure of ideal properties. Structures and techniques are also provided for replacing thick, heavy blocks of ferromagnetic material with thin straps and for extending the magnetostatic potential of a component in a magnetic structure by connecting a thin strap thereto and embedding the strap in the magnetic structure along an equipotential surface of the magnetic field generated by the magnetic structure.

Strapped open magnetic structure

A magnetic structure generating a substantially uniform magnetic field within a region of interest comprising at least one pair of magnetic wedges of substantially identical shape arranged symmetrically about a first axis and abutting one another along a common edge. Each magnetic wedge has a first side and a second side which terminate at the common edge. The first wedge of each pair is positioned to define a first angle between the first side and the first axis and a second angle between the second side and the first axis, and is uniformly magnetized in a direction relative to a second axis (perpendicular to the first axis) which is a function of the sum of the first and second angles. The second wedge of each pair is magnetized such that the absolute values of components of the magnetization along the first and second axes are equal to components of the magnetization of the first wedge along the first and second axes, respectively, and one of the magnetization components of the second wedge is opposite to the respective magnetization component of the first wedge. The region of interest containing the substantially uniform field is between the first sides of the pair of wedges, the second sides of the pair of wedges, or both. To minimize or eliminate the surface charge density along the third side of each wedge, the third side of each wedge is preferably parallel to the direction in which the wedge is magnetized.

Apparatus for generating uniform magnetic fields with magnetic wedges

A hybrid permanent magnet structure for providing a uniform magnetic field within a region of interest while allowing access via open ends by a patient for NMR scanning and by a surgeon to the patient via a large opening at the top. The magnet structure comprises nested inner and outer magnetic structures separated by ferromagnetic material and surrounded by a ferromagnetic yoke. The inner magnetic sections comprise end blocks of triangular cross-section, and the outer magnetic sections comprise end blocks of trapezoidal cross-section. Field distortion compensating means is provided by a primary filter structure to the ferromagnetic material and by magnetic insertions or a secondary filter structure.

Open permanent magnet structure for generating highly uniform field

A technique is provided for improving the homogeneity of the magnetic field within a cavity disposed inside a magnetic structure that has an opening to permit convenient access to an imaging region. The technique is based upon the step of inserting layers of magnetized material between plates of high magnetic permeability material. The layers are inserted at the boundary of the cavity. The technique includes the step of (1) computing the surface charges on the plates as used to derive the distribution of the magnetostatic potential, (2) analyzing the uniformity of the magnetic field within the imaging region as effected by the opening in the magnetic structure by expanding the magnetostatic potential in a spatial harmonic series, and (3) determining the geometry and the composition of the inserted layers based on the successive elimination of increasing orders of spatial harmonics in the potential expansion within the imaging region. This invention also includes the structure resulting from carrying out the technique of the invention.

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Scarsdale, NY, United States of America

Jens Jensen