Pharmacia & Upjohn Ab

Gs Development Ab

Pharmacia Ab

Kabi Pharmacia Ab

Dumex-alpharma A/s

Jens Hansen

Tomas Norling

Lise Sylvest Nielsen

Birgitte Mollgaard

Kurt Hedegaard

Sten Albrechtsen

Lene Orup-Jacobsen

Sten Albrectsen

Bo Kreilgangrd

Lone Norgaard Jensen

Use of fatty acid esters as bioadhesive substances. The fatty acid esters have molecular weights below about 1000 dalton and the fatty acid component of the fatty acid ester is a saturated or unsaturated fatty acid having a total number of carbon atoms of from C,to C,. Particularly suitable fatty acid esters for use according to the invention are fatty acid esters which are selected from the group consisting of fatty acid esters of polyhydric alcohols, fatty acid esters of hydroxycarboxylic acids, fatty acid esters of monosaccharides, fatty acid esters of glycerylphosphate derivatives, fatty acid esters of glycerylsulfate derivative, and mixtures thereof. Excellent bioadhesive properties have been observed for fatty acid esters are glyceryl monooleate, glyceryl monolinoleate or glyceryl monolinolenate. Methods are described for administering an active or protective substance to undamaged or damaged skin or mucosa of an animal such as a human by combining the active or protective substance with a bioadhesive fatty acid ester. The mucosa may be the oral, aural, nasal, lung, gastrointestinal, vaginal, or rectal mucosa. The administration may also be to body cavities such as the oral cavity, e.g. via buccal administration.

Use of fatty acid esters as bioadhesive substances

A pharmaceutical multiple unit particulate formulation in the form of coated cores which includes a pharmaceutically acceptable carrier selected from calcium carbonate, calcium silicate, calcium magnesium silicate, calcium phosphate, kaolin, sodium hydrogen carbonate, sodium sulfate, barium carbonate, barium sulfate, magnesium sulfate, magnesium carbonate, and activated carbon, and an active substance in a layer on the outer surface of the cores.

Pharmaceutical multiple unit particulate formulation in the form of

Use of fatty acid esters as bioadhesive substances. The fatty acid esters have molecular weights below about 1000 dalton and the fatty acid component of the fatty acid ester is a saturated or unsaturated fatty acid having a total number of carbon atoms of from C.sub.8 to C.sub.22. Particularly suitable fatty acid esters for use according to the invention are fatty acid esters which are selected from the group consisting of fatty acid esters of polyhydric alcohols, fatty acid esters of hydroxycarboxylic acids, fatty acid esters of monosaccharides, fatty acid esters of glycerylphosphate derivatives, fatty acid esters of glycerylsulfate derivative, and mixtures thereof. Excellent bioadhesive properties have been observed for fatty acid esters are glyceryl monooleate, glyceryl monolinoleate or glyceryl monolinolenate. Methods are described for administering an active or protective substance to undamaged or damaged skin or mucosa of an animal such as a human by combining the active or protective substance with a bioadhesive fatty acid ester. The mucosa may be the oral, aural, nasal, lung, gastrointestinal, vaginal, or rectal mucosa. The administration may also be to body cavities such as the oral cavity, e.g. via buccal administration.

Composition for drug delivery comprising nicotine or a derivative

##STR1## Occlusive epicutaneous testing strip and method for demonstrating whether or not an individual suffers from contact allergy to a test substance. The test strip has at least one patch on which the test substance is incorporated in a vehicle formulated as a film which adheres to the patch and contains at least one film-forming polymer capable of absorbing moisture which when the strip is being used is secreted from the skin area tested. The characteristic feature of the strip is that on at least one of the patches on which said vehicle is formulated as a film the said polymer has the structure (I), where n is the number of times that the structure within brackets is repeated and may be .gtoreq.100, and A is a straight or branched alkylene group having a length of 3-5 carbon atoms.

Test patch and its use for demonstrating contact allergy

Product to be used in occlusive epicutaneous testing for the purpose of

The present invention concerns a transdermal system with a reservoir layer comprising an active substance, at least part of which is in the form of an inclusion complex formed between a cyclo compound and the active substance. The release rate from the system is controlled by the dissociation of the complex.

Transdermal system

Growing community of inventors

Allerod, Denmark

Jens Hansen