Bayer Cropscience Ag

Bayer Intellectual Property Gmbh

Jens-Dietmar Heinrich

Norbert Lui

Thomas Wollner

Christian Funke

Sergii Pazenok

Thomas Norbert Müller

Reinhard Lantzsch

Thomas Himmler

Alexander Straub

Pierre-Yves Coqueron

Wahed Ahmed Moradi

Stefan Antons

Michael Dockner

Frank Volz

Günter Schlegel

Wolfgang Jörges

Stéphane Caillon-Morisseau

Robert Lui

Jürgen Wieschmeyer

James Mark Ford

Jürgen Wieschemeyer

Process for preparing 2,2-difluoroethylamine derivatives, wherein compounds of the general formula (IV) are reduced to the corresponding 2,2-difluoroethylamine derivatives of the general formula (III), where the A radical is as defined in the description: 

Method for preparing 4-aminobut-2-enolides

A process for the preparation of 2,2-difluoroethylamine of the formula (I)CHFCHNH&#x2003;&#x2003;(I)comprising the stages (i) and (ii):stage (i): reaction of 2,2-difluoro-1-haloethane of the formula (II)CHF&#x2014;CHHal&#x2003;&#x2003;(II)in which Hal is chlorine, bromine or iodine,with prop-2-en-1-amine of the formula (III) to give N-(2,2-difluoroethyl)prop-2-en-1-amine of the formula (IV) preferably in the presence of an acid scavenger,andstage (ii): removal of the allyl group from the N-(2,2-difluoroethyl)prop-2-en-1-amine of the formula (IV) obtained in stage (i) to give 2,2-difluoroethylamine of the formula (I) or a salt thereof.

Process for the preparation of 2,2-difluoroethylamine starting from prop-2-en-1-amine

The present invention relates to a process for the preparation of enaminocarbonyl compounds of the formula (I) where compounds of the formula (II) are reacted in the presence of a Br&#xf8;nsted acid to give compounds of the formula (I), and A, R1 and Z are as defined in the description, and also corresponding starting compounds which are used in the process according to the invention.

Method for producing enaminocarbonyl compounds

The present invention relates to a process for preparing enaminocarbonyl compounds by reacting compounds of the formula (II) with compounds of the formula (III) in which the A, R, Rand Z radicals are each as defined in the description, in the presence of a Br&#xf8;nsted acid.

The present invention relates to a process for the regioselective synthesis of 1-alkyl-3-halo-alkylpyrazole-4-carboxylic acid derivatives by cyclization of 2,3-disubstituted acrylic acid derivatives, and to the hydrazones formed as intermediates in the process.

Method for the regioselective synthesis of 1-alky1-3-haloalkyl-pyrazole-4-carboxylic acid derivatives

The present invention relates to a new process for preparing dithiine-tetracarboxy-diimides.

Process for preparing dithiine-tetracarboxy-diimides

Method for the regioselective synthesis of 1-Alkyl-3-haloalkyl-pyrazole-4-carboxylic acid derivatives

Process for the preparation of 2,2-difluoroethylamine derivatives of the formula (IV) comprising the steps (i) and (ii):step (i): reaction of N-(2,2-difluoroethyl)prop-2-en-1-amine of the formula (I) with a compound of the formula (II)A-CH-E&#x2003;&#x2003;(II)to give a compound of the formula (III) optionally in the presence of an inorganic or organic base, and step (ii): removal of the allyl group from the compound of the formula (III), in which, in the formulae (II), (III) and (IV), A and E have the meanings given in the description.

Process for the preparation of 2,2-difluoroethylamine derivatives starting from N-(2,2-difluoroethyl)prop-2-en-1-amine

A process for the preparation of 2,2-difluoroethylamine, comprising the reaction of 2,2-difluoro-1-chloroethane with an imide of the formula (II) in the presence of an acid scavenger, to give a compound of the formula (III) in which, in the compounds of the formulae (II) and (III), Rand Rare, each independently of one another, hydrogen or C-C-alkyl or Rand Rform, together with the carbon atoms to which they are bonded, a six-membered aromatic ring which is optionally substituted; and the cleavage of 2,2-difluoroethylamine by reaction of the compound of the formula (III) with acid, base or hydrazine.

Process for the preparation of 2,2-difluoroethylamine

The present invention relates to a process for the preparation of 5-substituted 1-alkyltetrazoles.

Process for the preparation of 5-substituted 1-alkyltetrazoles

The present invention relates to a process for preparing 4-aminobut-2-enolides and also corresponding intermediates and starting compounds which are passed through or used in the process according to the invention.

Method for producing 4-aminobut-2-enolides

Process for preparing 2,2-difluorethylamine derivatives of the general formula (III) in which A is an optionally substituted heterocycle as described in the description, by reacting a 2,2-difluoroethyl-1-haloethane compound of the general formula (I) in which Hal is Cl, Br or iodine, with an amine of the general formula (II) in which A is as defined above, optionally in the presence of a base.

Process for preparing 2,2-difluoroethylamine derivatives by alkylation with 2,2-difluoroethyl-1-haloethanes

Process for the preparation of 2,2-difluoroethylamine of the formula (I)CHFCHNH&#x2003;&#x2003;(I)comprising the stages (i) and (ii): 

Process for the preparation of 2,2-difluoroethylamine starting from a benzylamine compound

Process for preparing 2,2-difluoroethylamine derivatives, wherein compounds of the general formula (IV) are hydrogenated to the corresponding 2,2-difluoroethylamine derivatives of the general formula (III), where the A radical is as defined in the description: 

Method for producing 2,2-difluoroethylamine derivatives by imine hydrogenation

Process for preparing 2,4-dioxotetrahydrofuran-3-carboxylates of the formula (I) and/or (I') comprising the reaction of a haloacetyl chloride compound of the formula (II) with a malonic ester of the formula (III) in which Hal, Rand Rhave the definitions stated in the application, in the presence of a suitable base and optionally in the presence of a solvent; the addition of a sufficient amount of water to the reaction mixture; and the isolation of the desired 2,4-dioxotetrahydrofuran-3-carboxylate.

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Burscheid, Germany

Jens-Dietmar Heinrich