Dsm IP Assets B.v.

Academisch Ziekenhuis Maastricht

Covestro B.v.

University Maastricht

Maastricht Universitair Medisch Centrum+

Jens Christoph Thies

Edwin Currie

George Mihov

Jacob Koenen

Ruud Jozef Regina Wilhelmus Peters

Patrick Wilhelmus Antonius Vrijaldenhoven

Keqi Gan

Pieter J Emans

Guido J W Meijers

Paul Holmes

John Alan Lawton

Rudy Rulkens

Steven Peter Armes

Guy Draaisma

Nanning Joerg Arfsten

Jigeng Xu

Aylvin J A A Dias

Jun Qiu

Edwin Peter Kennedy Currie

Hermanus Adrianus Langermans

Pascal Jozef Paul Buskens

Guido Jozefina Wilhelmus Meijers

Astrid Franken

David L Winmill

Xiaorong You

Mirian Hendrika Jacoba Gillissen-Van Der Vight

Gueorgui Mihov

Mirian Hendrika Jacoba Gillisen-van Der Vight

Johannes L M Op Den Kamp

Aylin Jorge Angelo Athanasius Dias

Op Den Johannes Leonardus Maria Kamp

Detlef Olaf Alexander Schumann

Steven Armes

Franciscus Wilhelmus Maria Gelissen

Alex Kristian Roth

Hendrik Oevering

The disclosure relates to methods of making an osteoconductive polymer article for use as an orthopedic implant comprises steps of forming an article from a biocompatible, non-biodegradable polymer, the article comprising a non-flat surface with roughness Ra of at least 5 μm; providing a dispersion of bioactive ceramic particles of particle size at most 10 μm in a first solvent comprising a solvent for the polymer; coating at least the non-flat surface with the dispersion in at least one step; and rinsing the coated article with a second solvent being a non-solvent for the polymer to substantially remove the first solvent.

Method of making an osteoconductive polymer article and an osteoconductive polymer article thus made

The present invention relates to fibers comprising a polyesteramide (PEA) having a chemical formula described by structural formula (IV), wherein

Fibers comprising polyesteramide copolymers for drug deliver

The disclosure relates to methods of making an osteoconductive polymer article for use as an orthopedic implant comprises steps of forming an article from a biocompatible, non-biodegradable polymer, the article comprising a non-flat surface with roughness Ra of at least 5 &#x3bc;m; providing a dispersion of bioactive ceramic particles of particle size at most 10 &#x3bc;m in a first solvent comprising a solvent for the polymer; coating at least the non-flat surface with the dispersion in at least one step; and rinsing the coated article with a second solvent being a non-solvent for the polymer to substantially remove the first solvent. Further disclosed is an osteoconductive polymer article for use as an orthopedic implant, which article is made from a biocompatible, non-biodegradable polymer and comprises a non-flat surface with roughness Ra of at least 5 &#x3bc;m, wherein bioactive ceramic particles of particle size at most 10 &#x3bc;m are partly embedded in the polymer at the surface of the article. The methods exhibit benefits in ease of modifying a surface layer with bioactive particles, applying mild conditions and not requiring use of further additives or post-treatments, or without significantly affecting bulk polymer properties, and result in an orthopedic implant article having particles adhering to the surface while still being accessible for interaction with surrounding tissue or fluid.

The present inventioN relates to fibers comprising a polyesteramide (PEA) having a chemical formula described by structural formula (IV), wherein &#x2212;m+p varies from 0.9-0.1 and q varies from 0.1 to 0.9, &#x2212;m+p+q=1 whereby m or p could be 0, &#x2212;n is about 5 to about 300; (pref. 50-200), &#x2014;Ris independently selected from the group consisting of (C-C) alkylene or (C-C) alkenylene and combinations thereof; &#x2014;Rand Rin a single backbone unit m or p, respectively, are independently selected from the group consisting of hydrogen, (C-C)alkyl, (C-C)alkenyl, (C-C)alkynyl, (C-C)aryl, &#x2014;(CH)SH, &#x2014;(CH)S(CH), &#x2014;CHOH, &#x2014;CH(OH)CH, &#x2014;(CH)NH+, &#x2014;(CH)NHC(&#x2550;NH+)NH, &#x2014;CHCOOH, &#x2014;(CH)COOH, &#x2014;CH&#x2014;CO&#x2014;NH, &#x2014;CHCH&#x2014;CO&#x2014;NH, &#x2014;CHCHCOOH, CH&#x2014;CH&#x2014;CH(CH)&#x2014;, (CH)&#x2014;CH&#x2014;CH&#x2014;, HN&#x2014;(CH)&#x2014;, Ph-CH&#x2014;, CH&#x2550;C&#x2014;CH&#x2014;, HO-p-Ph-CH&#x2014;, (CH)&#x2014;CH&#x2014;, Ph-NH&#x2014;, NH&#x2014;(CH)&#x2014;C&#x2014;, NH&#x2014;CH&#x2550;N&#x2014;CH&#x2550;C&#x2014;CH&#x2014;. &#x2014;Ris selected from the group consisting of (C-C)alkylene, (C-C)alkenylene, alkyloxy or oligoethyleneglycol, &#x2014;Ris selected from bicyclic-fragments of 1,4:3,6-dianhydrohexitols of structural formula (III); &#x2014;Ris selected from the group consisting of (C-C)aryl (CC)alkyl, &#x2014;Ris &#x2014;(CH)4-; whereby a is at least 0.05 and b is at least 0.05 and a+b=1. 

Fibers comprising polyesteramide copolymers for drug delivery

The present disclosure relates to fibers implantable in the body of a human or animal and processes for manufacturing such a fiber. The fiber undergoes a reduction in surface area to volume ratio of a factor of 1.05-10 upon injection in the human or animal body. In an embodiment, a process for manufacturing a fiber comprises extruding a biodegradable polymer into a fiber capable of fitting in a syringe needle of at least 25 Gauge, and cooling the fiber below its dry glass transition temperature while the fiber is under tension.

Fiber comprising a biodegradable polymer

The present invention relates to a composition suitable for forming an optical coating, the composition comprising core-shell nanoparticles, wherein said nanoparticles comprise: (a) core material comprising polymer; and (b) shell material comprising metal oxide.

Core-shell nanoparticles

Drug delivery compositions are provided having proteins and biodegradable polymers that may be used for controlled and long term release of proteins into a biological environment. According to some embodiments, the drug delivery composition may be provided with at least a protein and a biodegradable polymer possessing at least two different functional groups selected from the group of chosen among carboxyl, ester, amine, amide, thiol, thioester or hydroxyl groups pendant to the main polymer chain whereby the composition absorbs between 5-10% w/w water when exposed to physiological conditions for at least 20 days. A drug delivery system for controlled protein release which includes the drug delivery composition is also provided whereby the drug delivery system may be in the form of microparticles, films, coatings, fibers, pellets, cylinders, discs, implants, microcapsules, microspheres, nanospheres, wafers, micelles, liposomes or woven or non-woven fabrics.

Drug delivery composition comprising proteins and biodegradable polyesteramides

The invention relates to an article comprising a substrate and a nano-porous coating, wherein the reflectivity of the article is less then 2%, and whereby the amount of sodium measured in the coating by XPS is less then 1 wt %, and further to a method of making the article.

Articles comprising porous coatings

A process for producing a coating composition includes separately chemically grafting particles with compounds having reactive groups and compounds having hydrophilic polymer chains. The hydrophilic polymer chains dissolve in water at least one temperature between 0 and 100&#xb0; C. The reactive groups may react with the substrate and or react with one another to form a cross-linked coating, comprising the particles. A process for forming a coating on a substrate is also provided.

Coating composition, coating and an object coated with the coating composition

The invention relates to a micro-porous membrane comprising a porous membrane carrier made of a first polymeric material (A) and comprising a second polymeric material (B) intimately divided throughout the porous membrane carrier, wherein the porous membrane carrier comprises a plurality of interconnected polymeric fibers, fibrils, filaments and/or lamellae having a thickness of less than 1 &#x3bc;m, the porous membrane carrier has an interconnected open porous structure formed by the plurality of interconnected polymeric fibers, fibrils, filaments and/or lamellae and a porosity of at least 50%; and the polymeric material (B) comprises a thermoplastic polycondensation polymer and is present in an amount of at most 30 wt. %, relative to the total weight of (A) and (B). The invention also relates to a process for preparing such a micro-porous membrane comprising steps wherein (i) a porous membrane carrier made of a first polymeric material (A) is impregnated with a polymer solution comprising a second polymeric material (B) in a solvent system (X), and (ii) the resulting impregnated membrane carrier is quenched in a non-solvent system (Y), thereby precipitating at least part of the second polymeric material (B).

High performance membrane

The invention relates to new processes for the preparation of antireflective coatings and coated substrates, as well as articles produced by these processes. These coatings can include one or more layers made of materials which form nano-structured and/or nano-porous surfaces. The process can include applying a cross-linkable hard coat to a substrate, partially curing or cross-linking the hard coat, and then applying a second coat carried by a solvent or mixture of solvents capable of swelling the partially cured hard coat. The second coat is then cross-linked and grafted to the hard coat to produce a durable coated substrate with antireflective properties.

Method of preparing nano-structured surface coatings and coated articles

Single layer anti-reflective hard-coat and methods of making same are disclosed and in particular comprise a structured surface, preferably a nano-structured surface. The hard-coat preferably a hardness above 0.5 GPa, more preferably above 0.7 GPa and most preferably above 1.0 GPa as measured by nano-indentation and/or a reduced tensile modulus above 3 GPa, more preferably above 8.5 GPa or 20 GPa, most preferably above 40 GPa as measured by nano-indentation and/or a scratch resistance above 5 mJ &#x3bc;m-3, preferably above 15 or 30 mJ &#x3bc;m-3, preferably above 60 mJ &#x3bc;m-3 as measured by nano-indentation, and/or contains an amount of inorganic nano-particles from 5 to 75 weight %, preferably from 15 to 50 weight % relative to the weight of the second material present in the hard-coat. Preferably, the spatial length scale of the refractive index gradient in the single layer hard-coat is between 10 and 1000 nm; in particular between 100 and 200 nm.

Preparation of a mechanically durable single layer coating with anti-reflective properties

The invention relates to a radiation curable composition comprising relative to the total weight of the composition (A) 0&#x2013;29 wt % of a cationically curable component having a linking aliphatic ester group, (B) 10&#x2013;85 wt % of an epoxygroup containing component other than A, (C) 1&#x2013;50 wt % of an oxetanegroup containing component, (D) 1&#x2013;25 wt % of a multifunctional acrylate and a radical photoinitiator and a cationic photoinitiator.

Radiation curable resin composition and rapid prototyping process using the same

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Maastricht, Netherlands

Jens Christoph Thies