Koninklijke Philips Corporation N.v.

Jens Christoph Georgi

Bernd Schweizer

Carolina Ribbing

Martin Weibrecht

Heinrich Von Busch

A therapy system includes a diagnostic image scanner () that acquires a diagnostic image of a target region to be treated. A planning processor () is configured to generate a patient specific adaptive radiation therapy plan based on patient specific biomarkers before and during therapy. A first set of patient specific biomarkers is determined then used for the determination of a first normal tissue complication probability (NTCP) model and a first tumor control probability (TCP) model. A radiation therapy device () administers a first dose of radiation to the target region with a protocol based on the first NTCP model and the first TCP model. A second set of patient specific biomarkers is determined. A relationship between the first set and second set of patient specific biomarkers is used to determine a second NTCP model and a second TCP model. The radiation therapy device () administers a second dose of radiation to the target region with a protocol based on the second NTCP model and second TCP model.

Marker adapted normal tissue complication probability

An apparatus, method, system, computer-readable medium and use for individual patient therapy planning of diseases such as cancer for different therapy modalities, such as radiation therapy and chemotherapy is provided. A new aspect of the invention is that the degree of bone marrow depression of the patient is related to the count of immature blood platelets, which are measured before each treatment. Some embodiments of the invention provide an advantage allowing reducing the level of uncertainty in the prediction of the risk of bone marrow depression, and thus enabling to safely improve the therapy effect by an increase of the radiation dosage and/or chemical dosage to the individual patient while the risk for bone marrow depression is minimized.

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Aachen, Germany

Jens Christoph Georgi