Pfizer Corporation

Massachusetts Institute of Technology

Jens Bertil Ahman

Stephen L Buchwald

John P Wolfe

Alan John Pettman

Michael Palucki

Ken Kamikawa

Robert Walton

Paul Blaise Hodgson

Malisa Troutman

Barry Richard Dillon

Andre Chieffi

Sarah Jane Lewandowski

The invention provides a process for producing a compound of formula (I), wherein Y is selected from the group consisting of CH, CHOH, CHCHOH, CHBr and Br; comprising the steps of:   The above process may also be used in the production of tolterodine and fesoterodine, which are useful in the treatment of overactive bladder.

Process for the production of benzopyran-2-ol derivatives

The present invention provides transition-metal-catalyst-based methods for the arylation and vinylation of activated methyl, methylene, and methine carbons with aryl halides, vinyl halides, and the like. The methods of the invention provide several improvements over existing methods, including the ability to synthesize efficiently and under mild conditions &#x3b1;-aryl and &#x3b1;-vinyl products from a wide range of starting materials, including ketones, esters, hydrazones, and imines. Furthermore, the methods of the invention may be used in an asymmetric sense, i.e. to produce enantiomerically-enriched chiral &#x3b1;-aryl and &#x3b1;-vinyl products.

Arylation and vinylation of activated carbons

Process for the production of quinazolines

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Sandwich, United Kingdom

Jens Bertil Ahman