Nitrokemia Ipartelepek

Nehezvegyipari Kutato Intezet

Mta Mezogazdasagi Kutato Intezet

Jeno Pelyva

Zoltan Kolonics

Csaba Soptei

Laszlo Lendvai

Lajos T Nagy

Bela Karacsonyi

Sandor Balint

Laszlo Legradi

Elemer Tomordi

Dezso Sebok

Janosne Benczik

Sandor Laszlo

Pal Agocs

Csaba Kayos

Miklos Kovacs

Miklos Nadasy

Andras Horvath

Judit Benczik Nee Pasztor

Andras Vass

Balint Nagy

Ervin Vertesi

K Istvan Vecsey

Jolan Cseke

Tibor Kranitz

Kornelia Domjan Nee Pinter

Endre Sumegi

Gyorgy Huszak

Bela Gyorfi

Ferenc Fodor, Deceased

Laszlo J Szabo

Andras Haas

Taszlo Kulcsar

Sandor Silye

Erzsebet Dioszegi

Process for the preparation of N-phenyl-N-methoxyacetyl-DL-alanine methyl ester derivatives of the formula (I). ##STR1## wherein R is a C.sub.1-4 alkyl residue; and n is a cardinal number between from 1 to 3, which comprises reacting an N-methoxyacetyl derivative of the formula (II). ##STR2## wherein R and n are as defined above, with a stoichiometric amount of an alkaline metal alkoxide, at a temperature between 80.degree. C. and 150.degree. C., until completion of the removal of the alkanol present in the system, then reacting the thus obtained alkaline metal salt of the compound of formula (II) directly or after isolation with a methyl DL-x-halopropionate.

Process for preparing N-phenyl-N-methoxyacetyl-DL-alanine methyl ester

The invention relates to an improvement of a process for preparing N-phosphonomethyl-glycine by oxydation of N-phosphonomethyl-imino-diacetic acid in an aqueous sulphuric acidic medium with hydrogen peroxide. A characteristic feature is using a waste acid liquor as reaction medium formed as aqueous sulphuric acid and obtained after the separation of N-phosphonomethyl-glycine when carrying out oxydation. This solution is optionally diluted with water until a concentration of 12-18 weight % of sulphuric acid and 3-5 weight % of N-phosphonomethyl-glycine.

Process for preparing N-phosphonomethyl-glycine

A process for preparing methoxyacetic acid by reacting monochloroacetic acid with sodium methylate, in a methanolic solvent at increased temperature. Methanol is distilled off and methoxyacetic acid methylester is added to the residue. The stirrable mixture is contacted with dry hydrochloric acid gas. The methoxyacetic acid methylester is distilled off after removing the precipitated sodium chloride, to recover the desired product.

Process for preparing methoxyacetic acid

The invention relates to the preparation of N-phosphono-methyl-imino-diacetic acid from the calcium salt of imino-diacetic acid in a simplified synthesis. The process comprises in that the imino-diacetic acid calcium salt is heated with concentrated hydrochloric acid in a molar ratio of 2-3:1 at a temperature between 50.degree.-100.degree. C., the obtained imino-diacetic acid hydrogen-chloride is separated then dissolved in water and is reacted with phosphorous acid in a molar ratio of 1.0-1.2:1 calculated for imino-diacetic acid hydrogen chloride and with the aqueous solution of formaldehyde in a molar ratio of 1.0-1.4:1 under stirring, and the obtained product is isolated.

Process for preparing N-phosphono-methyl-imino-diacetic acid

Process for the preparation of

The invention relates to an improved method for the preparation of a 2',6'-dialkyl-N-alkoxymethyl-2-chloro-acetanilide compound of the general formula (I), ##STR1## wherein R.sub.1, R.sub.2 and R.sub.3 are identical or different and stand for straight-chained or branched C.sub.1-4 alkyl groups. According to the invention a dialkyl aniline of the general formula (II), ##STR2## wherein R.sub.1 and R.sub.2 are as defined above, is treated with aqueous formaldehyde solution in an apolar solvent at a temperature of 30.degree. to 80.degree. C., the solution of the resulting oxymethyl derivative formed with said apolar solvent is separated from the aqueous formaldehyde solution at an elevated temperature and then dehydrated, the resulting azomethine derivative is reacted with chloroacetyl chloride in the same apolar solvent medium, the resulting chloromethyl compound is reacted with an alcohol of the general formula (V),

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Fuzfogyartelep, Hungary

Jeno Pelyva