Allergan, Inc.

Jenny W Wang

David Frederick Woodward

Jose L Martos

Jussi J Kangasmetsa

William Robert Carling

Neil J Poloso

Robert M Burk

William R Carling

Michael E Garst

Todd S Gac

Steven Dabbs

Simon Neil Pettit

Hans G Fliri

Clive L Cornell

Julia Herrmann

Ming Ni

William C Carling

The present invention provides a compound, that is a 1-({halo-2-[(2-hydrocarbyl or substituted hydrocarbyl)oxy]phenyl}methyl)-(fused bicyclic nitrogen heteroaryl) carboxylic acid or an ester or sulfonamide thereof. The compound may be represented by the following formula Wherein R, R, R, RA, X, W, Z and Y are as defined in the specification. The compounds may be administered to treat DP, FP, EP1, TP and/or EP4 receptor-mediated diseases or conditions.

Compounds acting at multiple prostaglandin receptors giving a general anti-inflammatory response

Disclosed herein are methods, compounds, and compositions for fat reduction, and in particular fat reduction without significant hair growth and/or additional hair growth.

Methods for fat reduction

Methods and compositions for stimulating the growth of hair are disclosed wherein said compositions include bimatoprost and minoxidil in a vehicle for topical application to the skin of a mammal, e.g. a human, whereby the combination of bimatoprost and minoxidil produces a faster onset of hair growth in humans or other mammals and wherein said composition brings about a synergistic result of faster onset of hair growth as compared to compositions comprising bimatoprost and minoxidil, alone.

Composition of enhancing hair growth

Compounds, processes for their preparation, pharmaceutical compositions containing such compounds and their use in treating therapeutic conditions, in particular conditions mediated by the action of ligands on the FP, DP, EP, EP, IP, DP, FP and TP prostaglandin (PG) receptors thereby providing a general anti-inflammatory response.

Antagonists acting at multiple prostaglandin receptors for the treatment of inflammation

The present invention provides a compound, that is wherein Y, W, Z, R1, R2, R4, R5 and R6 are as defined in the specification. The compounds may be administered to treat DP, FP, EP1, TP and/or EP4 receptor-mediated diseases or conditions.

Provided herein, inter alia, are, methods of using esters of bimatoprost with the Formula (I): 

Substituted cyclopentanes for inducing hair growth

The present invention provides compounds, that are N-alkyl-2-(1-(5-substituted-2-(3-oxo-3-(trifluoromethylsulfonamido)propyl)benzyl)pyrrolidin-2-yl)oxazole-4-carboxamide wherein the 5 substituent is selected from the group consisting of halo and alkyloxy radicals. The compound may be represented by the following formula 

Compounds act at multiple prostaglandin receptors giving a general anti-inflammatory response

The present invention provides a compound, that is a 1-[(2-{[(alkyl or aryl)methyl]oxy}halo or haloalkyl substituted-phenyl)alkyl]-5-hydrocarbyl or substituted hydrocarbyl-1H-pyrazole carboxylic acid or alkylenylcarboxylic acid or a hydrocarbyl or substituted hydrocarbyl sulfonamide of said carboxylic acid or said alkylenylcarboxylic acid, provided however said compound is not a 3-carboxylic acid, a sulfonamide thereof, or a 3-methylenylcarboxylic acid. The compound may be represented by the following formula 

Embodiments described herein are directed to prostanoid (IP) receptor agonist compounds, including cicaprost and certain prodrugs, and methods of preparation and use for the same. Certain embodiments are directed to the use of cicaprost and certain prodrugs in the treatment of topical and ocular conditions.

Prostanoid receptor agonist compounds and methods of use for same

There are provided inter alia methods and compounds useful for decreasing choroidal neovascularization in a subject in need thereof.

Inhibition of neovascularization by inhibition of prostanoid IP receptors

There are provided inter alia methods and compounds useful for decreasing neovascularization (e.g., choroidal neovascularization) in a subject in need thereof.

Growing community of inventors

Irvine, CA, United States of America

Jenny W Wang