Membrane Technology and Research, Inc

Pp Holdings Inc.

Jenny Louie

Richard W Baker

Johannes Gerard Wijmans

Frank Kochinke

Dan Arenson

William R Pfister

Peter H Pfromm

A transdermal delivery system for the modulated administration of drugs is described. The drug delivery device comprises a backing; a drug reservoir containing the drug, a plasticizer-type enhancer, a solvent-type enhancer, and optionally, a gelling agent; a non-rate-controlling membrane; and an adhesive layer containing a plasticizer-type enhancer. This drug delivery system is particularly useful for the administration of tolerance-inducing drugs, for example, vasodilators, such as isosorbide dinitrate.

Transdermal delivery systems for the modulated administration of drugs

An ultrathin, high-flux composite membrane for use in gas separation. The membrane comprises a metal layer, typically 500.ANG. or less thick on a microporous support. The support may be as asymmetric Loeb-Sourirajan type membrane or a two-layer composite of a microporous substrate with a very thin sealing layer. The support gives mechanical strength to the membrane but does not contribute significantly to the selectivity. Optionally the metal layer may be overcoated with a second polymeric sealing layer to plug any defects and to protect the fragile surface from mechanical damage. The membrane is particularly useful in the purfication of hydrogen.

Ultrathin composite metal membranes

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Fremont, CA, United States of America

Jenny Louie