US Genomics, Inc.

Quest Diagnostics Investments, Inc.

Jenny Ellen Rooke

Charles M Strom

Donghui Huang

Steven J Potts

Martin Fuchs

Eugene Y Chan

Steven R Gullans

Jeffrey D Randall

Xiaojian (David) Zhao

Bijit Kundu

Jessica Kesty

The present invention provides methods of determining the size of a particular nucleic acid segment of interest in a sample of nucleic acids through fragmentation of DNA, size fractionation, an optional second fragmentation, and identification using a marker sequence. In particular aspects, an expansion or reduction of tandem repeat sequences can be detected. In further aspects, carriers and individuals afflicted with fragile X syndrome or other diseases associated with tandem repeats can be distinguished from normal individuals.

Nucleic acid size detection method

The invention relates to methods for analyzing and characterizing single polymers such as nucleic acid molecules. In preferred embodiments, the single molecules are analyzed using single molecule detection and analysis systems.

Methods and apparati using single polymer analysis

Growing community of inventors

Seattle, WA, United States of America

Jenny Ellen Rooke