University of California

University of Rhode Island Research Foundation

Blue Ocean Barns

Jennifer Smith

William H Gerwick

David C Rowley

Hannah Resetarits

Hyuakjae Choi

Joan Salwen

Gal Dishon

Matthew Rothe

Lena Gerwick

Francisco Villa

Vivienne Hay

A novel and distinct variety of, provided as a source of halogenated compounds.

algae named 'Brominata'

The invention provides novel compositions based on a structure designated as 'Honaucin A', including Honaucin A variants and analogs, and pharmaceutical compositions, liposomes and nanoparticles comprising them, and methods of making and using them. In one embodiment, these Honaucin A compounds, and variants and analogs thereof are used to ameliorate (including to treat or prevent) inflammation. In one embodiment, these Honaucin A compounds, and variants and analogs thereof are used to ameliorate (including to treat or prevent) inflammation. In one embodiment, these Honaucin A compounds, and variants and analogs thereof are used as bacterial quorumsensing inhibitors. Accordingly, in alternative embodiments the compositions of the invention are used as anti-bacterial agents.

Anti-inflammatory and quorum sensing inhibition compounds and methods of making and using them

Growing community of inventors

San Diego, CA, United States of America

Jennifer Smith