Radiomedix Inc.

Jennifer Sims-Mourtada

Izabela Tworowska

Ebrahim S Delpassand

Ali Azhdarinia

The invention provides D02S derivatives conjugated to monosaccharide ligands directly or through a linker and optionally chelated to a metal, wherein the D02S derivatives having the following structure: wherein R', R&#x2032; are each independently &#x2014;OH or &#x2014;O-alkyl; Ris a hydrogen, a linker, or a ligand; Ris a linker and/or a ligand; and n is an integer from 1 to 10; the linker is an amino acid, a peptide, an amino alcohol, a polyethylylene glycol, an alkyl, an alkenyl, an alkynyl, an azide, an aromatic compound, a carboxylic acid, or an ester, the alkyl, alkenyl, or alkynyl is optionally substituted with an alkyl, a halogen, a nitro group, a hydroxyl group, an amino group, or a carboxyl group; the ligand is a GLUT1 targeting moiety.

Compositions, methods of synthesis and use of carbohydrate targeted agents

The present invention relates to the field of radiochemistry, nuclear imaging, radionuclide therapy and chemical synthesis. More particularly, it concerns a strategy for radiolabeling target ligands. It further concerns methods of using those radiolabeled ligands for imaging, radionuclide therapy and tissue-specific disease imaging.

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Bellaire, TX, United States of America

Jennifer Sims-Mourtada