Zymergen Inc.

Shell Oil Comapny

Topaz Biosciences, Inc.

Jennifer Shock

Oliver Liu

Jeffrey Kim

Louis Clark

William W Hwang

Zachariah Serber

Douglas A Hattendorf

Teresa Shock

Alexander Neckelmann

Xiao Yang

Eyal Akiva

Stephanie Leanne Brown Hendrix

Maritza Miller

Tom Hayon Eyles

Samuel Oteng-Pabi

Claus Pelikan

Ute Galm

Devin Scannell

Sangita Ganesh

Michael Sneddon

Maritza Duarte

The present disclosure relates to novel cell wall binding domains, enzymatically active domains, and chimeric cell wall hydrolases with anti-activity. The disclosure also relates to compositions comprising these, and uses thereof in the treatment of conditions associated with

Cell wall hydrolases targeting c. acnes

The present disclosure relates to novel chimeric cell wall hydrolases with anti-activity. The disclosure also relates to compositions comprising these chimeric cell wall hydrolases and uses thereof in the treatment of conditions associated withsp.

Recombinant cell wall hydrolases

The present disclosure provides methods and systems for identifying natural product-encoding multi-gene clusters (MGCs). In some embodiments, the present disclosure also teaches methods for producing sequenced and assembled metagenomic libraries that are amenable to MGC search bioinformatic tools and techniques.

Metagenomic library and natural product discovery platform

The present disclosure provides methods and systems for identifying natural product-encoding multi-gene clusters (MGCs). In some embodiments, the present disclosure also teaches methods for producing sequenced and assembled metagenomic libraries that are amenable to MGC search bionformatic tools and techniques.

The disclosure presents a platform for discovering novel insecticidal proteins from highly heterogeneous environmental sources. The methodology utilizes metagenomic enrichment procedures and unique genetic amplification techniques, which enables access to a broad class of unknown microbial diversity and their resultant proteome. The disclosed insecticidal protein discovery platform (IPDP) can be computationally driven and is able to integrate molecular biology, automation, and advanced machine learning protocols. The platform will enable researchers to rapidly and accurately access the vast repertoire of untapped insecticidal proteins produced by uncharacterized and complex microbial environmental samples. Also presented herein are a group of newly discovered pore-forming toxins (PFT) from a rare class of insecticidal proteins, which were discovered utilizing the insecticidal protein discovery platform.

Insecticidal protein discovery platform and insecticidal proteins discovered therefrom

The disclosure is directed to an approach for discovering novel insecticidal proteins from highly heterogeneous environmental sources. The methodology utilizes metagenomic enrichment procedures that increase the representation of specific genera of bacteria, prior to deep sequencing, in order to access novel variants of insecticidal proteins. In aspects, the taught methods are useful for creating large genomic libraries enriched forsp. The enriched genomic libraries are useful for the discovery of novel cry toxin genes, which enable the identification of novel Cry proteins.

Method for creating a genomic library enriched forand identification of novel cry toxins

This invention provides microbial organisms, particularly yeasts such as, that have one or more disrupted genes. The gene disruption(s) may yield improved production of fatty acyl-CoA derivatives.

Gene disruptants producing fatty acyl-CoA derivatives

The present invention provides promoters derived from a filamentous fungus. These promoters have application in the fields of molecular biology, microbiology, fungal genetics and production of biofuels and other products.

Growing community of inventors

San Francisco, CA, United States of America

Jennifer Shock