Johnson & Johnson Pharmaceutical Research & Development, LLC

Medvet Science Pty Ltd

Jennifer Ruth Gamble

Stuart Maxwell Pitson

Brian Wolff Wattenberg

Pu Xia

Mathew A Vadas

Matthew Alexander Vadas

Richard James D'Andrea

Philip Barter

Kerry-Anne Rye

Phillip Barter

Kerry Anne Rye

The invention relates to detection of sphingosine kinase activity and sphingosine kinase agonist or antagonist activity.

Detection of sphingosine kinase activity and sphingosine kinase agonist or antagonist activity

The present invention relates generally to novel protein molecules and to derivatives, analogues, chemical equivalents and mimetics thereof capable of modulating cellular activity and, in particular, modulating cellular activity via the modulation of signal transduction. More particularly, the present invention relates to human sphingosine kinase and to derivatives, analogues, chemical equivalents and mimetics thereof. The present invention also contemplates genetic sequences encoding said protein molecules and derivatives, analogues, chemical equivalents and mimetics thereof. The molecules of the present invention are useful in a range of therapeutic, prophylactic and diagnostic applications.

Sphingosine kinase enzyme

The present invention relates generally to novel protein molecules and to derivatives, analogues, chemical equivalents and mimetics thereof capable of modulating cellular activity and, in particular, modulating cellular activity via the modulation of signal transduction. More particularly, the present invention relates to human sphingosine kinase and to derivatives, analogues, chemical equivalents and mimetics thereof. The present invention also contemplates genetic sequences encoding said protein molecules and derivatives, analogues, chemical equivalents and mimetics thereof. The molecules of the present invention are useful in a range of therapeutic, prophylactic and diagnostic application.

A screening method for identifying a therapeutic candidate for a coronary heart disease or an inflammatory condition is disclosed. The screening method tests for the presence or absence of an effect by a putative therapeutic agent on a component of a sphingosine kinase signaling pathway.

Screening method for an agent having an effect on a sphingosine kinase signaling pathway

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Stirling, Australia

Jennifer Ruth Gamble