Elan Pharmaceuticals, Inc.

Jennifer Marugg

Martin Neitzel

Michael A Pleiss

Jay S Tung

Darren B Dressen

Jing Wu

Albert W Garofalo

R Jeffrey Neitz

Michael S Dappen

Ashley C Guinn

David W G Wone

The invention provides N-substituted benzenesulfonamides for use in treating or preventing cognitive disorders, such as Alzheimer's Disease. Compounds of particular interest are defined by Formula (I), wherein R, R, R, R, and R, are as described in the specification. The invention also encompasses pharmaceutical compositions comprising compounds of Formula (I) as well as methods of treating cognitive disorders, including Alzheimer's disease using compounds of Formula (I).

N-substituted benzene sulfonamides

Disclosed are N-substituted benzenesulfonamides for use in treating or preventing cognitive disorders, such as Alzheimer's Disease.  In Formula (I), R, R, R, R, R, Rand Rare as described herein. The invention also encompasses pharmaceutical compositions comprising compounds of Formula (I) as well as methods of treating cognitive disorders using compounds of Formula (I).

Disclosed are compounds that are bradykinin Breceptor antagonists and are useful for treating diseases, or relieving adverse symptoms associated with disease conditions, in mammals mediated by bradykinin Breceptor. Certain of the compounds exhibit increased potency and are also expected to exhibit increased duration of action.

[object Object]

Disclosed are compounds of formula I and II that are bradykinin Breceptor antagonists and are useful for treating diseases, or relieving adverse symptoms associated with disease conditions, in mammals mediated by bradykinin Breceptor. Certain of the compounds exhibit increased potency and are also expected to exhibit increased duration of action. 

Disclosed are N-substituted benzenesulfonamides for use in treating or preventing cognitive disorders, such as Alzheimer's Disease. In Formula (I), R, R, R, R, R, Rand Rare as described herein. The invention also encompasses pharmaceutical compositions comprising compounds of Formula (I) as well as methods of treating cognitive disorders using compounds of Formula (I).

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San Jose, CA, United States of America

Jennifer Marugg