Abbvie Inc.

Abbvie Deutschland Gmbh and Co Kg

Merial Limited

Other

Disc Medicine, Inc.

Uerial LLC

Jennifer Maria Perez

Chung-Ming Hsieh

Lorenzo Benatuil

Yuliya Kutskova

John Memmott

Anca Clabbers

Suju Zhong

Margaret Hugunin

Bernhard K Mueller

Andreas Popp

Edit Tarcsa

Michel Joseph Bublot

Mary Leddy

Anwar Murtaza

Bradford L McRae

Craig Wallace

Shaughn H Bryant

Edward B Reilly

Andrew C Phillips

Catherine Elisabeth Charreyre

Jonathan P Belk

Steven Robinette

Carrie Goodreau

Christine Michele Pierrette Andreoni

Lucia Eaton

Alyssa Brito

Francis Jean-Christophe Audonnet

Christine Mich&egrave;le Pierrette Andreoni

John Quisel

Brian MacDonald

Maria Beconi

Michel Bublot

Aspects of the application provide anti-hemojuvelin antibodies and methods of using the same in treating myelofibrosis and/or conditions associated with myelofibrosis.

Anti-hemojuvelin (HJV) antibodies for treating myelofibrosis

Provided herein are methods of using the antibodies that bind to RGMc to treat and diagnose iron-related disorders.

Composition and method for the diagnosis and treatment of iron-related disorders

The invention relates to anti-epidermal growth factor (EGFR) antibodies and antibody drug conjugates (ADCs), including compositions and methods of using said antibodies and ADCs.

Anti-EGFR antibodies and antibody drug conjugates

System and methods are disclosed for identifying and isolating antibodies with specific affinity with an antigen of interest. Multiple DNA libraries encoding antibodies or their fragments are designed such that the encoded antibodies from different libraries are tagged differently. These libraries may be transformed into yeast cells. The variants of the antibodies are displayed on the surface of the yeast cells and flow cytometry may be used to sort the cells based on antigen affinity and the different tags on the antibodies. By allowing multiple libraries to be screened simultaneously, the disclosed methods help improve the efficiency of affinity.

High-throughput system and method for identifying antibodies having specific antigen binding activities

Isolated binding proteins, e.g., antibodies or antigen binding portions thereof, which bind to tumor necrosis factor-alpha (TNF-&#x3b1;), e.g., human TNF-&#x3b1;, and related antibody-based compositions and molecules are disclosed. Also disclosed are pharmaceutical compositions comprising the antibodies, as well as therapeutic and diagnostic methods for using the antibodies.

Immunobinders directed against TNF

Proteins that bind IL-17 and/or IL-17F are described along with their use in composition and methods for treating, preventing, and diagnosing IL-17 related diseases and for detecting IL-17 in cells, tissues, samples, and compositions.

IL-17 binding proteins

Engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention, diagnosis, and/or treatment of disease are provided.

Bispecific antibodies directed against TNF-&#x3b1; and IL-17

Proteins that bind IL-17 and/or IL-17F are described along with their use in compositions and methods for treating, preventing, and diagnosing IL-17 related diseases and for detecting IL-17 in cells, tissues, samples, and compositions.

This invention is directed to the transformation of yeast, and mutants thereof, by electroporation, which result in stably transformed yeast host cells that express recombinant products. This invention also is directed to transformed yeast cells and libraries.

Methods for transforming yeast

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Worcester, MA, United States of America

Jennifer Maria Perez