Waters Technologies Corporation

Jennifer M Nguyen

Matthew A Lauber

Henry Y Shion

Robert Birdsall

Ximo Zhang

Nilini Ranbaduge

Kevin Daniel Wyndham

Thomas H Walter

Mathew H DeLano

Gregory T Roman

Melvin Blaze Muttikal Thomas

Yun Wang Alelyunas

Mathew Delano

The present disclosure relates to a method of reducing degradation of sample components in a liquid chromatography system. The method utilizes a masked metal frit to prevent or reduce metal surfaces from becoming catalytically active. The masked metal frit is a metal based frit that includes a coating on its exterior surfaces to mask or prevent contact between the organic solvents (and/or any analyte or other related solvent) and the underlying metal. The coating is a vapor deposited inorganic-organic hybrid coating, such as a vapor deposited C2 coating.

Chromatographic hardware improvements for separation of reactive molecules

The present disclosure provides devices, systems, kits and methods useful for quantitation of biomolecules such as intact proteins and nucleic acids.

Devices and methods for the sensitive detection and quantitation of biomolecules

The present disclosure relates to the determination of analytes in a sample using chromatography. The present disclosure provides methods of separating an analyte from a sample. A mobile phase is flowed through a chromatography column. The mobile phase includes about 0.005% (v/v) to about 2.50% (v/v) difluoroacetic acid and less than about 100 ppb of any individual impurity, especially metal impurities. A sample including the analyte is injected into the mobile phase. The analyte is separated from the sample.

Difluoroacetic acid ion pairing reagent for high sensitivity, high resolution LC-MS of biomolecules and small molecules

The present disclosure relates to the determination of analytes in a sample using chromatography. The present disclosure provides methods of separating an analyte from a sample. A mobile phase is flowed through a chromatography column. The mobile phase includes about 0.005% (v/v) to about 0.20% (v/v) difluoroacetic acid and less than about 100 ppb of any individual metal impurity. A sample including the analyte is injected into the mobile phase. The analyte is separated from the sample.

Difluoroacetic acid ion pairing reagent for high sensitivity, high resolution LC-MS of biomolecules

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Uxbridge, MA, United States of America

Jennifer M Nguyen