National Technology & Engineering Solutions of Sandia, LLC

Jennifer Lauren Schwedler

Brooke Nicole Harmon

Yooli Kim Light

Maxwell Stefan

Catherine Margaret Mageeney

Ramdane Abdallah Harouaka

Michael Bartsch

Christopher Sumner

Disclosed herein are single-domain antibodies (sdABs) configured for targeting to human or mammalian lung tissue. Constructs and methods of using such sdABs are also described herein, such as methods of binding with and transporting other sdABs or other cargo with beneficial functionalities, binding to and transporting biochemical or pharmaceutical species with beneficial functionalities, and a method of treating, diagnosing, or prophylactically treating a disease, condition, or malignancy. A purification method for in vivo treatment or testing is also provided.

Lung-targeting single-domain antibodies and purification methods

Provided herein are single domain antibodies (sdAbs) configured for passing the blood brain barrier in a human or mammal brain. Methods of using such sdAbs are also described herein, such as methods of binding to brain cells, binding with and transporting other sdAbs with beneficial functionalities, binding to and transporting biochemical or pharmaceutical species with beneficial functionalities, and treating, diagnosing, or prophylactically treating a disease, malignancy, or condition.

Brain-targeting single domain antibodies and purification methods

The present disclosure relates to methods, apparatuses, and systems to measure one or more electrical signals from a cultured cell layer. In some embodiments, such electrical signals can be indicative of transport or lack of transport of an agent through the cell layer.

Real-time patch-clamp sensing of transport across a barrier tissue

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Livermore, CA, United States of America

Jennifer Lauren Schwedler