Abbott Laboratories Corporation

Jennifer L Che

Andrew J Souers

Philip R Kym

Michael A Patane

Anil Vasudevan

Matthew J LaMarche

Rajesh R Iyengar

Martin P Maguire

Su-Jen Lai

Mathew M Mulhern

Christopher Blackburn

Courtney A Cullis

Dariusz Wodka

Ju Gao

John K Lynch

Jennifer C Freeman

James A Brown

Mary Katherin Verzal

Matthew J Lamarche

James Brown

Mary Katherine Verzal

This invention provides compounds that are antagonists of melanin concentrating hormone receptor-1 (MCH-R1). The compounds are represented by formula I:where m is zero or one, n is zero to two, Y is oxygen or &#x2014;N(R)&#x2014;, R, R, R, R, R, Rand Ring A are defined in the specification. Coumarin and quinolone compounds where Rand Rtogether form a fused benzo ring are preferred. The invention also provides compounds of formula VI where the coumarin moiety is replaced by a quinazolinone ring. The compounds are useful for treating MCH-R1-related disorders, particularly overweight conditions including obesity.

Antagonists of melanin concentrating hormone receptor

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Cambridge, MA, United States of America

Jennifer L Che