Medibeacon Inc.

Jennifer Keating

Kate LeeAnn Bechtel

Edward Gerald Solomon

Kimberly Merritt Shultz

Kimberly Schultz

Kate Bechtel

A method of assessment of renal function by monitoring a time-varying fluorescence signal emitted from a fluorescent agent from within a diffuse reflecting medium with time-varying optical properties is provided that includes using a renal monitoring system comprising at least one light source, at least one light detector, at least one optical filter, and at least one controller to provide a measurement data set comprising a plurality of measurement entries, each measurement data entry comprising at least two measurements obtained at one data acquisition time from a patient before and after administration of the fluorescent agent.

Method for non-invasive monitoring of fluorescent tracer agent with diffuse reflecting medium with time-varying optical properties

A method of monitoring a time-varying fluorescence signal emitted from a fluorescent agent from within a medium with time-varying optical properties is provided that includes providing a measurement data set that includes a plurality of measurement entries that include at least two measurements obtained from a patient before and after administration of the fluorescent agent. The measurements may include one or more of: a DRsignal detected by an unfiltered light detector during illumination by excitatory-wavelength light from first region adjacent to the diffuse reflecting medium; a Flr signal detected by a filtered light detector during illumination by excitatory-wavelength light; and a DRsignal detected by the unfiltered light detector during illumination by emission-wavelength light. The method further includes identifying a post-agent administration portion of the measurement data set; and transforming each Flr signal to an IF signal representing a detected fluorescence intensity emitted solely by the fluorescent agent.

Method for non-invasive monitoring of fluorescent tracer agent with diffuse reflection corrections

A method of monitoring a time-varying fluorescence emitted from a fluorescent agent from within a diffuse reflecting medium with time-varying optical properties is disclosed that includes providing at least two measurements obtained from a patient before and after administration of the fluorescent agent that includes an Flrsignal detected adjacent to the medium by a filtered light detector during illumination of the medium by excitatory-wavelength light, and at least one DR signal selected from: a DRDR, and DRsignal. The method further includes identifying a post-equilibration portion of the measurement data set and transforming each Flrsignal within the post-equilibration portion of the measurement data set to an IFsignal representing a detected fluorescence intensity emitted solely by the fluorescent agent from within the medium. The disclosed method includes removing the effects of leak-through of excitation-level light and removing the effects of autofluorescence from the Flrsignal.

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Mountain View, CA, United States of America

Jennifer Keating