Debregeas Et Associes Pharma

Stanipharm

Ethypharm, Inc.

Jennifer Jung

Pascal Suplie

Catherine Herry

Frantz Deschamps

Fabrice Leboeuf

Christophe Lebon

The present invention relates to a novel method for obtaining a pharmaceutical composition based on modafinil. This method consists of solubilizing S modafinil in a fluid in the supercritical state and then after expansion of said fluid, recovering S modafinil by causing it to be absorbed at the surface by a support appearing as granules. Said fluid may be COor another solvent and the support, anhydrous lactose or mannitol. Application of the pharmaceutical composition in the cases when increased short term alertness and over a short period is required for the consumer of the pharmaceutical composition.

Process for obtaining a modafinil-based pharmaceutical composition, resulting pharmaceutical composition and use thereof

The present invention relates to a method for preparing solid pharmaceutical compositions comprising fine particles of at least one active substance, dispersed on and (or) within a divided solid. This method is characterized in that a solution is formed which comprises at least one active substance in a fluid at supercritical pressure, said solution then being expanded in a chamber under temperature and pressure conditions for which a part of said fluid is in the liquid state at the time of the expansion, said fluid thus expanded being brought into contact with a divided solid in said chamber.

Method for preparing pharmaceutical compositions comprising fine particles of active substance

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Dieulouard, France

Jennifer Jung