Genetics Institute, Inc.

Jennifer Chen

Lih-Ling Lin

Andrea R Schievella

James R Graham

Novel TNF receptor death domain ('TNF-R1-DD') ligand proteins are disclosed. Polynucleotides encoding the TNF-R1-DD ligand protein are also disclosed, along with vectors, host cells, and methods of making the TNF-R1-DD ligand protein. Pharmaceutical compositions containing the TNF-R1-DD ligand protein, methods of treating inflammatory conditions, and methods of inhibiting TNF-R death domain binding are also disclosed. Methods of identifying inhibitors of TNF-R death domain binding and inhibitors identified by such methods are also disclosed.

TNF receptor death domain ligand proteins and inhibitors of ligand binding

Novel TNF receptor death domain (&ldquo;TNF-R1-DD&rdquo;) ligand proteins are disclosed. Polynucleotides encoding the TNF-R1-DD ligand protein are also disclosed, along with vectors, host cells, and methods of making the TNF-R1-DD ligand protein. Pharmaceutical compositions containing the TNF-R1-DD ligand protein, methods of treating inflammatory conditions, and methods of inhibiting TNF-R death domain binding are also disclosed. Methods of identifying inhibitors of TNF-R death domain binding and inhibitors identified by such methods are also disclosed.

TNF receptor death domain ligand proteins

TNF receptor death ligand proteins and inhibitors of ligand binding

TNF receptor death domain ligand proteins and method to identify

TNF receptor death domain ligand proteins and inhibitors of ligand

MADD, a TNF receptor death domain ligand protein

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Jennifer Chen