Abbott Laboratories Corporation

Jennifer C Freeman

Steven Armen Boyd

Gui-Dong Zhu

Indrani W Gunawardana

Michael A Staeger

Andrew O Stewart

Meena V Patel

Pramila A Bhatia

David M Stout

David L Arendsen

Nicholas A Mort

Catherine M McCarty

John K Lynch

Kraig Lartey

Kevin R Condroski

Gang Liu

Andrew J Souers

Philip R Kym

Michael A Patane

Martin Winn

Zhili Xin

Anil Vasudevan

Zhonghua Pei

Matthew J LaMarche

Rajesh R Iyengar

Martin P Maguire

James T Link

Hwan-soo Jae

Su-Jen Lai

Mathew M Mulhern

Courtney A Cullis

Christopher Blackburn

Dariusz Wodka

Ju Gao

Sheldon Wang

Tom W Von Geldern

James A Brown

Mary Katherin Verzal

Matthew J Lamarche

Jennifer L Che

James Brown

Mary Katherine Verzal

This invention provides compounds that are antagonists of melanin concentrating hormone receptor-1 (MCH-R1). The compounds are represented by formula I:where m is zero or one, n is zero to two, Y is oxygen or &#x2014;N(R)&#x2014;, R, R, R, R, R, Rand Ring A are defined in the specification. Coumarin and quinolone compounds where Rand Rtogether form a fused benzo ring are preferred. The invention also provides compounds of formula VI where the coumarin moiety is replaced by a quinazolinone ring. The compounds are useful for treating MCH-R1-related disorders, particularly overweight conditions including obesity.

Antagonists of melanin concentrating hormone receptor

The present invention relates to novel cinnamide compounds that are useful for treating inflammatory and immunune diseases, to pharmaceutical compositions containing these compounds, and to methods of inhibiting inflammation or suppressing immune response in a mammal.

Cell adhesion-inhibiting antiinflammatory and immune-suppressive compounds

Cell adhesion-inhibiting antiinflammatory compounds

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Grayslake, IL, United States of America

Jennifer C Freeman